Thrombectomy catheter EKOS™

pulmonary

Product summary
EKOS is an endovascular thrombolysis system for targeted treatment of pulmonary embolism that combines localized ultrasonic energy with low-dose thrombolytic infusion to accelerate clot dissolution. The system is designed for minimally invasive catheter-directed therapy, enabling access to distal pulmonary vessels and providing increased ultrasound power in EKOS+ configurations for faster clot resolution.

Key features & benefits

• Minimally invasive catheter-directed procedure (typical procedure time ≈ 15 minutes)
• Low thrombolytic dose protocols (reported as low as 8 mg tPA in some regimens)
• Ultrasonic waves thin and separate fibrin strands to expose additional drug receptor sites and improve lytic distribution
• Acoustic streaming enhances intrathrombus drug penetration while reducing systemic exposure
• EKOS+ catheters deliver approximately 50% more ultrasound power while retaining the same procedure and workflow

Ultrasonic core technology
EKOS devices use an embedded ultrasonic core to generate a targeted acoustic field that drives thrombolytic agent deeper into thrombus and disrupts the fibrin matrix. This mechanism increases clot penetration, exposes plasminogen receptor sites, and supports more efficient thrombolysis compared with lytic infusion alone.

Clinical highlights

• Clinical trials report reductions in RV/LV ratio of ~23–25% within 24–48 hours
• Observed decreases in pulmonary artery pressures (reported reductions ~28% at 48 hours)
• Enables substantially lower thrombolytic dosing versus systemic therapy (reported reductions up to ~88–92%)
• Clinical studies report low rates of major bleeding and intracranial hemorrhage across evaluated cohorts

EKOS system components and workflow
EKOS comprises infusion catheters with an embedded ultrasonic core paired with a control unit. The system supports targeted acoustic pulse thrombolysis for pulmonary embolism and may be applied to other thrombotic conditions (e.g., selected deep vein thrombosis and arterial occlusions) per clinical protocols and labeling.

Control Unit (EKOS Control Unit 4.0)
The EKOS CU4.0 adds workflow-focused features including an interactive color touchscreen, an internal battery to maintain therapy during transport, and dual-channel ports to manage two EKOS devices simultaneously for bilateral PE treatment. CU4.0 maintains compatibility with earlier EKOS catheters and adds EKOS+ support.

Product literature (high level)
Product documentation is available, including instructions for use, clinical references, training checklists, and trial summaries. Consult labeling for indications, contraindications, and detailed usage guidance.

Technical specifications / ordering examples

• EKOS catheters: 5.4 F infusion catheter; available lengths: 106 cm and 135 cm (0.035" guidewire compatible); single ultrasonic core matched to catheter length; treatment zones vary by SKU (examples: 6–50 cm for 106 cm catheters; 12–50 cm for select 135 cm configurations).
• EKOS+ catheters: 7.8 F infusion catheter; available lengths: 106 cm and 135 cm (0.035" guidewire compatible); treatment zones typically ~8–20 cm for listed EKOS+ SKUs.
• EKOS Control Unit 4.0 (EKOS CU4.0): Equipment Class II (product code KRA in documentation); example power requirement: 250 VAC, 50/60 Hz; example dimensions: 26.9 x 22.7 x 11.4 cm; example weight: 12.5 lb. Features: touchscreen, internal battery, A/B channels, on-screen troubleshooting and workflow prompts.
• Ordering / sample SKU entries (examples):
  UPN/Order code | GTIN | Catheter length (cm) | Treatment zone (cm)
  500-55106 | 858593006028 | 106 | 6
  500-55112 | 858593006134 | 106 | 12
  500-55118 | 858593006141 | 106 | 18
  500-55124 | 858593006158 | 106 | 24
  500-55130 | 858593006165 | 106 | 30
  500-55140 | 858593006172 | 106 | 40
  500-55150 | 858593006189 | 106 | 50
  500-56112 | 858593006264 | 135 | 12
  500-56130 | 858593006295 | 135 | 30
  500-56140 | 858593006301 | 135 | 40
  500-56150 | 858593006318 | 135 | 50
  EKOS+ examples: H74939605106080 | 191506015459 | 106 | 8; H74939605106120 | 191506015466 | 106 | 12; H74939605106160 | 191506015473 | 106 | 16; H74939605106200 | 191506015480 | 106 | 20.
• Notes: Treatment zones and available lengths vary by SKU; consult product literature and ordering information for full SKU mapping, labeling, and safety information.