Microwave synthesis platform FLEX ISYNTH

robotized

Overview
Automated, parallel library synthesis and lead optimization for drug discovery (medicinal chemistry). Chemspeed’s fully automated, integrated FLEX ISYNTH is a flexible, modular automated solution that unlocks the chemical space via faster, better, virtually unrestricted exploration of reaction space, reagent space and molecule space. It executes conventional, microwave-assisted, photochemical and reactive-gas workflows in a fully automated fashion, including reaction preparation, multistep synthesis, work-up, purification, analysis and product transfer to storage.

Workflow (FLEX ISYNTH - Library synthesis)
Migrated workflow: FLEX ISYNTH - Library synthesis. Typical automated workflow steps and tools include:

• Inertization
• Gravimetric dispensing (solid)
• Volumetric dispensing (liquid)
• Heating while shaking
• Sampling (direct injection or into LC vial)
• Work-up (e.g. filtration, liquid/liquid extraction, SPE)
• Sample collection

Benefits

• Fully automated, integrated reaction preparation, synthesis, work-up, analysis and output to storage vials for solid- and liquid-phase library synthesis and reaction screening.
• Easy-to-use disposable multi-functional, high-precision glass reactor arrays; available reaction scales from μL to mL.
• Glass reactor arrays with screwless and self-sealing opening/closing; mixing by shaking (up to 1’700 rpm), heating (up to 150°C) and cooling (-20°C); capability for refluxing, vacuum, inertization, evaporation, liquid/liquid extraction, filtration, solid-phase extraction, crystallization and drying.
• Proprietary robotic tool exchange for flexible automation.
• Gravimetric solid handling from μg to g.
• Gravimetric liquid handling from mg to g and μL to mL.
• Chemistry-proven liquid handling features (e.g. pH control, filtration, heated needle extension).
• High throughput: e.g. 24 / 48 / 96 / ... parallel reactions per run depending on configuration.
• Integrated sampling and analytics: benchtop online NMR, HPLC (MS), UPLC (MS), GC (MS), UV-VIS, NIR / MIR / DLS measurement cell.
• Ventilated hood for safety and conditioned operation.
• AUTOSUITE software: drag & drop experiment design, easy interface with options for custom python device scripting and integration to LIMS, ELN, data analysis and AI/ML closed-loop workflows.

Technical specifications

• System: FLEX ISYNTH (fully automated, modular synthesis platform)
• Automation scope: reaction preparation, multistep synthesis, work-up, purification, analysis, product transfer to storage
• Reaction formats: solid-phase and liquid-phase library synthesis; reaction screening
• Reactor arrays: disposable, multi-functional glass reactor arrays; screwless self-sealing design
• Reaction scale: from μL to mL
• Mixing: shaking up to 1’700 rpm
• Temperature range: heating up to 150°C; cooling down to -20°C
• Capabilities: refluxing, vacuum, inertization, evaporation, L/L extraction, filtration, SPE, crystallization, drying
• Solid handling: gravimetric from μg to g
• Liquid handling: gravimetric from mg to g and volumetric from μL to mL
• Throughput: configurable parallel reactions (examples: 24 / 48 / 96 per run)
• Integrated analytics: online benchtop NMR, HPLC/MS, UPLC/MS, GC/MS, UV-VIS, NIR/MIR, DLS measurement cell
• Software: AUTOSUITE (drag & drop experiment design, integration to LIMS/ELN, AI/ML workflows)
• Safety/environment: ventilated hood for conditioned operation