Automated, parallel library synthesis / lead optimization in drug discovery (medicinal chemistry).
Overview
Chemspeed's solution
Molecules discovery (e.g. in medicinal chemistry) is driven more and more by the demand for innovative medicines which involves molecular diversity and novel routes, meaning more and more experiments typically with the same resources.
Chemspeed’s fully automated, integrated FLEX ISYNTH stands for a flexible, modular, and uncompromising automated solution that:
Unlocks the chemical space via faster, better, virtually unrestricted “off-road” chemistry investigation of the eeaction space, reagent space or molecule space.
Chemspeed’s ISYNTH deck modularity provides unrivalled versatility to execute and perform a variety of synthesis workflows (conventional, MW-assisted, photochem, reactive gas) in a fully automated fashion, including reaction preparation, multistep synthesis, work-up, purification, analysis and product transfer to storage.
Enhances your efficiency and productivity by a factor of up to 100 in, for example: C-C / C-N coupling reactions, organometallic reactions (e.g. Grignard), alkylations, Diels-Alder reactions and transfer hydrogenations.
Workflow
Example workflow
The interactive workflow panel below showcases example workflows for this solution. Each Chemspeed tool or module performs a set of specific actions, as in any manual lab workflow, and an almost limitless arrangement of these tools is possible.
Benefits
Powerful advantages
Fully automated, integrated reaction preparation, synthesis, work-up, analysis, output to storage vials for solid- and liquid-phase library synthesis as well as reaction screening.