Robotized synthesis platform AUTOPLANT POLY

high-throughput

Overview
Automated end-to-end platform for polymer synthesis, optimization and scale-up including reaction setup, controlled polymerization, work-up and analytical integration.

• Living/controlled polymerizations
• Emulsion polymerization
• Suspension polymerization
• Dispersion polymerization
• Solution polymerization
• Mass (bulk) polymerization
• Pressure polymerization

Technology & Key Features
Modular platform combining overhead gravimetric dispensing, individually controlled tank reactors and integrated process control to standardize and accelerate polymerization workflows.

• Individually controlled reactors with precise continuous feeds
• Reactor volumes: 100 mL, 240 mL, 1,000 mL
• Throughput: up to 12 / 24 syntheses per run on AUTOPLANT; up to 6 per run on semi-automated MULTIPLANT
• Exchangeable impellers (anchor, pitched/twisted blade, gas-entrainment)
• Mixing capability: up to 80 Pa·s at 300 rpm and 30 Pa·s at 900 rpm (anchor stirrer)
• Multiple continuous liquid, liquefied-gas and gas feeds per reactor
• Independent temperature and stirring control per reactor (example: >130°C active differential between adjacent reactors)
• Internal and/or jacket temperature control
• Pressure-rated operation up to 100 bar with safety systems
• Parallel high-performance calorimetry and viscosity acquisition
• PAT interfaces for in‑situ probes (pH, UV‑VIS, IR, Raman, PSD, calorimetry)
• Gas consumption measurement
• Dean–Stark trap and distillation bridge
• Vacuum capability for inertization, crystallization and other unit operations
• Supported unit operations: extraction, filtration, evaporation, crystallization, distillation
• Ventilated hood for safe and conditioned operation
• AUTOSUITE software: drag-and-drop experiment design, custom Python device support, integration with LIMS/ELN and AI/ML closed-loop workflows
• Optional integrated benchtop NMR (e.g. 80 MHz Fourier RxnLite) for online/offline profiling, 1D/2D spectra and flow-cell or 5 mm tube sampling

Workflow Steps (MULTIPLANT / AUTOPLANT POLY)

• Design of experiments (DoE)
• Preparation of monomer emulsions
• Preparation of initiator solutions
• Heating and controlled stirring
• Controlled co-feeds of monomer emulsions
• Controlled feed of initiator solution
• Quenching and termination
• Removal of excess surfactant and residual monomer
• Post-processing and application testing
• Analytical testing and data capture

Software & Integration
AUTOSUITE automates experiment design, execution, analysis and reporting with prebuilt workflows, drag-and-drop sequence building and integration to LIMS/ELN. Supports AI/ML closed-loop optimization and custom device drivers.

Technical specifications

• Reactor volumes: 100 mL, 240 mL, 1,000 mL (individually controlled)
• Syntheses per run: up to 12 / 24 on AUTOPLANT; up to 6 on semi-automated MULTIPLANT
• Mixing: up to 80 Pa·s at 300 rpm and 30 Pa·s at 900 rpm (anchor stirrer)
• Exchangeable stirrers: anchor, twisted blade, gas-entrainment, etc.
• Continuous feeds: flexible and precise; multiple liquid/liq. gas/gas feeds per reactor
• Temperature control: independent per reactor; internal and/or jacket control; active differential >130°C with cooling
• Pressure rating: up to 100 bar with safety installations
• Analytical: parallel calorimetry and viscosity measurement
• PAT support: pH, UV‑VIS, IR, Raman, PSD, calorimetry interfaces
• Gas consumption measurement
• Unit operations: Dean–Stark trap, distillation bridge, extraction, filtration, evaporation, crystallization, vacuum operations
• Safety/environment: ventilated hood for conditioned and safe operation
• Software: AUTOSUITE with LIMS/ELN and AI/ML integration
• Optional hardware: integrated benchtop NMR (e.g. 80 MHz Fourier RxnLite) supporting multiple nuclei, 1D/2D spectra, flow-cell or 5 mm tube sampling