Pregnancy test kit LYOFIA®

sFLt-1serumplasma

This Fluorescent Immunoassay PLGF and sFLT-1 POCT Kit is designed for in vitro quantitative detection of PLGF and sFLT-1 in whole blood ,serum and plasma samples. It’s for professional only. Summary Soluble fms-like tyrosine kinase-1 (sFlt-1) is a truncated tyrosine kinase form that disables proteins with antiangiogenic properties and a shortened non-membrane splice variant of VEGFreceptor 1 (Flt-1) that signals angiogenesis. It contains an extracellular domain identical to that of Flt-1, but lacks both the transmembrane and intercellular domains present in Flt-1.Instead, sFlt-1 contains a novel 31 amino acid C-terminal sequence and 6 immunoglobulin- like domains, with a binding site for VEGF and PIGF within the second domain from the N-terminus,resulting that sFlt-1 competes with Flt-1 to bind VEGF and PIGF, which effectively reducing serum concentrations of these two angiogenic growth factors. PlGF is a protein highly expressed by the placenta with vasculogenic and angiogenic properties, which has a central role in spiral artery remodeling and the development of a low-resistance placental capillary network. Increased rates of preterm birth Low PIGF levels in high-risk pregnant women between 20° and 36 weeks of gestation is associated with increased risk of early-onset pre-eclampsia Increased risk of stillbirth characterized by severe placental vascular disease. Principle The fluorescent immunoassay PLGF and sFLT-1 POCT kit adopts microfluidic fluorescence immunoluminescence method, Why Test sFLT-1 and PLGF? Pre-eclampsia (PE) is a complex multisystem disease of pregnancy globally responsible fora significant burden of maternal,perinatal,