Petri dish PICSI®

The PICSI® dish is a dish for intracytoplasmic sperm injection (ICSI) with hyaluronan microdots, supporting the selection of mature spermatozoa with better DNA quality.1,2 Supports the selection of mature spermatozoa with increased chromatin integrity, better DNA packaging, and reduced risk of aneuploidy.1-4 Simple implementation into clinical practice. Easy and convenient to use.5 Hyaluronan-based selection of spermatozoa for ICSI could be considered as part of the treatment plan for advanced age couples and patients with previous unsuccessful ICSI attempts.2,6 Significantly decreases miscarriage rates.7,8 Improves live birth outcomes among older couples and helps to mitigate the poor prognosis usually ascribed to advanced maternal age.2 May provide better treatment outcomes after previous failed ICSI cycles.6 Hyaluronic acid (HA) or hyaluronan is a naturally occurring organic polymer that is also a major component of the extracellular matrix of the oocyte-cumulus complex. During the natural fertilization process human oocytes are surrounded by hyaluronan, which is acting as a ‘‘physiologic selector’’ of spermatozoa.5 Only fully mature spermatozoa can bind to hyaluronan, as hyaluronan receptors appear on the plasma membrane during late spermiogenesis after the maturation-related plasma membrane remodeling. This is accompanied by the loss of the residual body via cytoplasmic extrusion, DNA repackaging from histones to protamines and zona pellucida-binding site formation.