Automatic dissolution tester HPLC On-/Offline System

for the pharmaceutical industrybenchtopdigital

The ERWEKA Dissolution HPLC On-/ Offline System is the semi-automated solution for 100% USP / EP / JP compliant dissolution testing with HPLC online analysis. Up to 5 out of 8 dissolution steps can be automated by combining one of our highly qualified dissolution testers of the DT 950 or DT 9510 series with devices for CTC sampling and online HPLC chromatography. The entire system is controlled by our Disso.NET software. For filtrations up to 0.22 µm, our automatic filter changer AFC 825 can be used in combination with our maintenance-free PVP pump. In addition to precise and simple control of the entire system, Disso.NET provides an accurate record of the entire test process, from the automatic recording of the sampling time to the recording of the temperature and rotation speed in each vessel (= documentation of all system processes, Audit Trail). After the dissolution test* with the DT 950 and double filtration with the PVP 820 pump and the AFC 825, the medium is transferred to the HPLC sampler. There, it is first filled into a transfer block (PEEK block) and then distributed into appropriate vials. If required, the samples can be diluted for immediate analysis or cooled and temporarily stored against UV radiation for later analysis. The HPLC analysis starts as soon as a sample is filled into the sampler's HPLC valve and a trigger signal is sent from Disso.NET to the HPLC device. The analysis and evaluation is carried out using the analysis software of the respective HPLC manufacturer on a separate PC.As the analysis times of the samples are defined in advance via the Disso.NET software