Packed-bed bioreactor TideXcell®

laboratoryfor cell culturefor the pharmaceutical industry

TideXcell® is a linearly scalable pilot bioreactor system that runs on Tide Motion principle. It is ideal for biomass expansion of adherent cells under single-use or multiple-use technologies. The pilot scale bioreactor is also integrated with desirable and advanced features such as pH and DO (Dissolved Oxygen) measurement capability, Siemens HMI or PLC-based monitoring and control system, compressed air path that comes with a double HEPA and VOC (volatile organic chemicals) filters as well as other accessories. Features Adherent cell scale-up for up to 5,000L packed-bed volume (bio-equivalency of 50,000 L in suspension) a 100% media exchange system ideal for continuous bioprocessing Separation of the matrix and mixing vessel -permits dual temperature control process to produce higher virus titers Built-in weighing platform and inhouse mixer PLC based monitoring system - with simple, intuitive touchscreen runs on Wonderware SCADA Can be connected to SCADA systems with DeltaV or Pcs7 controls Dual redundant systems - for critical components such as PLC and pumps are catered Provides an ultra-scale down process - and reduces costs by saving on media, labor, space, utilities, and most importantly, eliminates cross-contamination Isolator capability cGMP references PAT/IPQC Uniform Seeding TideXcell® Matrix Bed is designed to cut the area into numerous small sections and force cells to flow in horizontal radial direction instead of vertical direction. The gradient effect during the seeding phase could be minimized.