DNA microarray Infinium Core-24

Overview
The Infinium Core-24 Kit is a customizable genome-wide research genotyping array (24-sample BeadChip) for cost-effective large-scale human genotyping and population studies. It includes 307,342 fixed, highly informative tag SNPs across diverse populations, additional high-value markers (including indels and exome-focused content), and supports addition of up to 300,000 semi-custom markers. Designed for use with the Infinium assay and iScan System to enable high-throughput processing and consistent genome-wide data.

Notes
The product was previously marketed as HumanCore-24 BeadChip Kit; kits under either name contain the same reagents and follow the same workflow.

Key features

• Customizable genome-wide array with fixed content plus capacity for semi-custom content (up to 300,000 additional markers)
• Designed for large-scale human genotyping and population studies
• Supports detection of SNPs, indels, CNVs and other structural variants
• Works with the Infinium assay and iScan System; compatible with automated array loading and liquid-handling robotics

Product details (table)
Automation capability: Automated array loader, Liquid handling robot(s)
Description: A customizable research array that contains highly informative genome-wide tag SNPs found in diverse world populations, additional high-value markers (including indels and exome-focused content), and the capacity to add up to 300,000 semi-custom markers.
Input quantity: 200 ng
Instruments: iScan System
Method: High-throughput genotyping array, Genome-wide genotyping array
Nucleic acid type: DNA
Number of markers: 307,342 fixed markers; custom marker add-on capacity up to 300,000 (with + kit versions)
Number of samples: 24 samples per array
Sample throughput: ~2304 samples per week (estimate for 1 iScan System, 1 AutoLoader 2.x, 2 Infinium Automated Pipetting Systems, 5-day work week)
Species category: Human
Technology: Microarray
Variant class: Single nucleotide polymorphisms (SNPs), Germline variants, Structural variants, Insertions-deletions (indels), Copy number variants (CNVs)

Applications / Use cases

• Large-scale genotyping and genome-wide association studies
• Population-scale screening and multiethnic variant discovery
• Baseline datasets for ancestry, sex confirmation, mtDNA, CNV and common-variant analyses
• Workflow input for downstream analyses and informatics pipelines

Technical specifications

• Format: 24-sample BeadChip (per array)
• Fixed markers: 307,342
• Custom add-on capacity: Up to 300,000 semi-custom markers (with + kit versions)
• Recommended input DNA: 200 ng
• Compatible instrument: iScan System
• Automation: Supports Automated array loader and liquid-handling robots (Infinium automation kits)
• Assay: Infinium assay (microarray-based)
• Sample throughput estimate: ~2304 samples/week (1 iScan, 1 AutoLoader 2.x, 2 automated pipetting systems, 5-day week)
• Intended species: Human
• Variant classes interrogated: SNPs, indels, CNVs, structural and germline variants