The Rotarod test is widely used to evaluate drug effects on motor coordination, balance and motor learning in rodents. The principle of this test is that rats or mice are first trained to walk on a rod rotating at a certain speed. Once the animals have learned this, the effect of a test-compound on their motor performance is evaluated. Animals experiencing impaired motor coordination are unable to cope with the rotating rod and will drop off when the rotation speed exceeds their motor coordination capacity. When the animal drops from rod safely into its own lane, the time latency to fall is automatically recorded.