Zebrafish ECG Studies
In cardiovascular drug discovery, Zebrafish are used to model such processes as thrombosis, collateral vessel development, inflammation, cardiomyopathy, and cardiac regeneration.
The iWorx ZS-200 Zebrafish ECG Recording and Analysis System provides an ideal way to use this cost-effective model for high throughput, rapid screening of compounds. The LS-30ECG LabScribe3 ECG Analysis Module provides an array of analysis options including T and QT segment shortening and prolongation which are a key indicator of cardiac function.
The ZS-200 provides a compact, easy-to-use and non-invasive solution for investigation of cardiac side effects of a vast number of molecules.request-quote
Large Fish ECG systems are available. Contact us for details.
Missinato, Maria A., et al. “Dusp6 attenuates Ras/MAPK signaling to limit zebrafish heart regeneration.” Development145.5 (2018): dev157206.
Dvornikov, Alexey V., et al. “Phenotyping an adult zebrafish lamp2 cardiomyopathy model identifies mTOR inhibition as a candidate therapy.” Journal of molecular and cellular cardiology (2019).
Liu, Hao, et al. “Screening and identification of cardioprotective compounds from Wenxin Keli by activity index approach and in vivo zebrafish model.” Frontiers in Pharmacology 9 (2018): 1288.
Woods, Courtney Elizabeth. Development and validation of high-resolution cardiovascular phenotyping strategies in zebrafish reveals the clinical relevance of ROBO4 to congenital heart defects. Diss. Johns Hopkins University, 2017.
Please call us at 1-800-234-1757 to discuss how we can help advance your cardiac research.