Orthopedic surgery bone cement NEPTUN Fix G40-HV

Summary
NEPTUN Fix G40-HV is a high-viscosity, antibiotic-loaded bone cement for cemented arthroplasty. Designed for routine use in the operating room, it offers user-friendly working times, rapid curing, high form stability and antimicrobial action through the active ingredient gentamicin. The cement supports secure implant fixation and helps reduce the risk of bacterial colonization, particularly in the early postoperative phase.

Properties

• High-viscosity (good sculptability, form-stable for complex defects and revisions)
• User-friendly handling time and standardized temperature-time profile (defined mixing, waiting, application and curing phases)
• Rapid curing and high mechanical stability
• Antimicrobial activity due to added gentamicin sulfate (equivalent to 1 g pure gentamicin)
• Suitable for manual or machine vacuum mixing

Composition
Polymer:

• Polymethylmethacrylate 84.3 %
• Benzoyl peroxide 2.4 %
• Barium sulfate 9.6 %
• Gentamicin sulfate (equivalent to 1 g pure gentamicin) 3.8 %

Monomer:

• Methyl methacrylate 84.4 %
• Butyl methacrylate 13.2 %
• N,N-dimethyl-p-toluidine 2.4 %
• Hydroquinone 20 ppm

Processing & curing under OR conditions
NEPTUN Fix G40-HV is suitable for manual or machine vacuum mixing. Optimal processing temperature: 18–25 °C. The standardized temperature-time profile provides the surgical team with a clear working window including defined mixing, waiting, application and curing phases. The high viscosity allows good sculpting and ensures form stability even in more complex defects or revisions.

Temperature‑Time diagram
The temperature-time diagram indicates mixing time, working time and curing progression under standardized conditions and supports planning of the surgical workflow.

Antibiotic release
Antibiotic release graphs show the release profile of the added gentamicin; the formulation is designed for antimicrobial effect in the early postoperative phase.

Characteristics / Technical specifications

• Product name (model): NEPTUN Fix G40-HV
• Brand: LOSCH Medical
• Active ingredient: gentamicin sulfate (equivalent to 1 g pure gentamicin) 3.8 %
• Polymethylmethacrylate content in polymer: 84.3 %
• Barium sulfate as radiopacifier: 9.6 %
• Benzoyl peroxide (initiator): 2.4 %
• Monomer composition: methyl methacrylate 84.4 %, butyl methacrylate 13.2 %, N,N-dimethyl-p-toluidine 2.4 %, hydroquinone 20 ppm
• Processing temperature: 18–25 °C
• Mixing method: manual or machine (vacuum mixing suitable)
• Viscosity: high-viscosity (sculptable, form-stable)
• Application: cemented arthroplasty (implant fixation)