Electrophoretic light scattering nanoparticle size analyzer Zetasizer Lab

laserstatic light scatteringdynamic light scattering

Overview
The Zetasizer Lab is an entry‑level dynamic light scattering (DLS) and zeta potential instrument for particle and molecular size analysis. It integrates Adaptive Correlation, M3‑PALS and a constant‑current zeta mode, and supports extended size‑range analysis when used with the ZSU1002 low‑volume capillary cell. ZS Xplorer software provides data quality feedback and guided analysis.

Key features

• Classical 90° side‑scatter DLS for particle/molecular size (typical 0.3 nm–10 μm; up to 15 μm with extended analysis)
• M3‑PALS and constant‑current zeta mode for zeta potential and electrophoretic mobility
• Support for low sample volumes: size from 3 µL (capillary), zeta from 20 µL
• Static light scattering at 90° for molecular weight estimation
• On‑site upgrade path to Zetasizer Pro or Zetasizer Ultra
• Included ZS Xplorer analytics with instant data‑quality feedback

Model variants

• Blue Label — recommended for routine colloids (metallic colloids, metal oxides, pigments)
• Red Label — recommended for challenging samples (proteins, surfactant solutions, low solid content)

Which Zetasizer is right for me?
Comparison (overview): Zetasizer Ultra | Zetasizer Pro | Zetasizer Lab — Size principle: NIBS & MADLS | NIBS | Classical 90° DLS; Zeta principle: ELS with M3‑PALS & constant current (all models); Low‑volume capillary support: Yes | No | Yes.

Key applications

• Colloidal silica — reproducible sizing for quality control
• Titanium dioxide — aggregation/agglomeration and stability vs. pH or salt concentration
• Ceramics — particle size distributions and multimodal populations
• Proteins — low‑volume characterization using capillary cell
• Fluorescent nanomaterials (C‑dots) — measurement considerations for fluorescence
• Viral vectors (AAV) — size distribution and indicative titer (MADLS on Ultra for concentration/titer)

Technical specifications

• Measurement principle (size): Classical 90° DLS; measurement angles: 90°, 13°
• Size range: 0.3 nm – 15 μm (typical 0.3 nm–10 μm)
• Minimum sample volume (size): 3 µL (capillary)
• Zeta range: 3.8 nm – 100 μm; minimum volume (zeta): 20 µL; sample conductivity up to 260 mS/cm
• Static light scattering (molecular weight): Red Label 300 Da–20 MDa; Blue Label 980 Da–20 MDa (±10%)
• Detector: Avalanche photodiode; Laser: He‑Ne 633 nm (Blue 4 mW / Red 10 mW)
• Temperature control: 0 °C – 120 °C (dry N2 purge required below dewpoint)
• Dimensions: 322 × 565 × 245 mm; Weight: 19 kg; Power: AC 100–240 V, 50–60 Hz
• Standards: ISO22412:2025; ISO13099‑2:2025; relevant USP and ASTM methods