TDCS transcranial electrical stimulator

tACStRNStES

LOOP-IT is an all-in-one hardware platform for closed-loop, state-dependent neuroscience experiments combining multichannel stimulation and biosignal acquisition in a compact, medical-grade design. It enables synchronous EEG/ECG/EMG acquisition with multiple non-invasive stimulation modalities (tES, TMS, temporal interference, neuromuscular stimulation) and supports real-time, phase- or state-dependent control.

Features

• Galvanically isolated modules providing separate acquisition, stimulation and I/O functions
• Integrated biosignal acquisition chain for EEG, ECG and EMG
• Multichannel tDCS / tACS / tRNS current sources with low 1/f noise
• Multichannel digital I/O for triggers and synchronization (e.g., TMS timing, event markers)
• Additional sensor interfaces for movement, respiration, blood flow and temperature
• Real-time, state- and phase-dependent closed-loop control with minimized acquisition→analysis→actuation latency
• Direct hardware access through provided Python library
• Medical-grade, compact hardware with standard interfaces
• Operable from mains power or external battery pack

Applications

• Conventional TMS workflows: synchronized EMG for MEP studies, ECG for autonomic monitoring, EEG for cortical responses
• EEG + NIBS configurations for personalized, brain-state dependent protocols in rehabilitation and psychiatry (example: 8× EEG + 1× digital I/O)
• Temporal interference stimulation with multi-channel tES to target deeper structures by amplitude steering
• Combined tES & TMS for phase-dependent associative pairing to probe or modulate corticospinal plasticity (example: 1× tES + 1× digital I/O)

Accessories

• Wide range of EEG acquisition and tES accessories: electrodes (various sizes/shapes), cables, caps and conductive pastes; available individually or in kits

Technical specifications

• Data acquisition: ExG (EEG, ECG, EMG) up to 1 ksps
• Additional sensors: 3-axis accelerometer, 24-bit resolution @ 1 kHz
• Current sources: low 1/f noise, output < 5 mApp, bandwidth < 5 kHz (suitable for temporal interference)
• Closed-loop system turn-around time: approximately 1–3 ms (minimized constant delays between acquisition, analysis, event detection and output)
• Supports multi-channel transcranial stimulation configurations (2 or 4 stimulation channels depending on setup)
• Galvanic isolation between modules
• Direct hardware control via provided Python library
• Power: mains operation or external battery pack