Buccal tissue matrix creos™ xenoprotect

collagenxenograftabsorbable

Product overview
creos™ xenoprotect is a resorbable natural collagen membrane for guided bone regeneration (GBR) and guided tissue regeneration (GTR). It is composed of an interwoven network of highly purified porcine collagen and elastin fibers, providing mechanical strength and favourable handling characteristics.

Why creos xenoprotect?

• Clinical outcomes: randomized controlled data show 81% defect height reduction at 6 months for creos™ xenoprotect versus 62% for a reference membrane in one trial (24 vs 25 patients).
• Promotes bone healing: preclinical in vivo studies report significantly higher new bone formation in the central defect area and increased expression of BMP2 associated with osteogenesis.
• Favourable wound healing profile: low rates of wound dehiscence and membrane exposure reported in clinical studies.
• Designed to perform with low rates of complications based on clinical evidence.

Key performance and handling features

• Easy handling: does not adhere to instruments, repositionable in situ, low surface expansion when hydrated; both sides can face the defect.
• High mechanical strength: excellent suture retention and tear resistance to maintain space and stability.
• Enduring resistance to degradation in vivo: manufacturing preserves the natural collagen fiber network to confer increased resistance to enzymatic degradation (shown in animal models).

Clinical evidence and outcomes

• Randomized controlled clinical trial: 24 patients treated with creos™ xenoprotect vs 25 with a reference membrane—defect height reduction at 6 months was 81% vs 62% respectively.
• Multiple preclinical and clinical studies and multicenter investigations report favourable bone formation, tissue dynamics and mechanical stability (see product literature for references).

Typical clinical uses / indications

• Guided bone regeneration (GBR).
• Guided tissue regeneration (GTR).
• Horizontal and vertical ridge augmentation, defect fill, management of dehisced implant sites and other bone regeneration procedures.

Resources and supporting documentation
Product literature and downloadable technical documents (brochure, clinical and scientific literature review, white paper, patient information) are provided by the manufacturer with detailed instructions, indications, contraindications and prescribing information.

Technical specifications

• Composition: highly purified porcine collagen network with elastin fibers (native collagen membrane).
• Resorbable, non‑crosslinked membrane intended for GBR/GTR.
• Handling: non‑adherent to instruments; repositionable in situ; low surface expansion when hydrated; ambidirectional sides.
• Mechanical: high suture retention; tear‑resistant; high mechanical strength to maintain space and stability.
• Degradation: manufacturing preserves collagen fiber network to confer increased resistance to enzymatic degradation in vivo (preclinical evidence).
• Clinical performance: documented bone regeneration and high defect fill percentages in clinical trials.
• Consult manufacturer documentation for sizes, handling protocols, indications, contraindications and full prescribing information.