Xenograft bone substitute creos™ xenogain

for maxillofacial surgeryfor dental sugerygranules

Overview
creos™ xenogain is a xenogenic bone graft material developed for guided bone regeneration (GBR) and guided tissue regeneration (GTR). It is supplied sterile and available in vial, syringe and bowl formats to enable fast and easy clinical application.

Applications and formats

• Guided bone regeneration (GBR)
• Guided tissue regeneration (GTR)
• Sinus lift procedures
• Extraction socket management (creos™ xenogain collagen recommended)
• Available sterile in vial, syringe or bowl; collagen variant available in block form and syringe (contains 10% porcine collagen)

Material and biological properties
creos™ xenogain particles are composed of deproteinized bovine bone mineral matrix with preserved micro- and macrostructures. The preserved natural bone matrix and interconnected pore system provide a scaffold for new bone formation. Quality-controlled processing removes bovine proteins and lipids to ensure biocompatibility.

Key benefits & highlights

• Chemical composition similar to human bone (Ca/P ratio comparable)
• Interconnected macropores to support bone ingrowth
• Osteoconductive properties supporting dental implant treatment
• Long-term volume stability
• Uneventful healing reported in clinical use
• Homogeneous particle size for consistent handling
• Hydrophilic material for fast rehydration and improved handling

creos™ xenogain collagen
Purified cancellous bovine bone mineral granules combined with 10% porcine collagen in block form and syringe. The added collagen improves graft retention and is recommended for extraction socket management.

Clinical evidence (selected)
In a multicenter clinical study involving 46 patients, mean bone increase after 8 months was reported as 4.0 mm (+56.9% gain) and 4.7 mm (+51.0% gain) at 1 mm and 3 mm from the crest, respectively. GBR with creos™ xenogain supported robust bone regeneration and enabled placement of 91 implants in 43 patients (mean insertion torque 37.8 ± 5.1 Ncm).

Supporting points from product rationale

• Preservation of natural bone features through optimized manufacturing
• Chemical composition and low crystallinity support biological acceptance as a scaffold
• Provides a framework that integrates with new bone to support implant placement

Technical specifications

• Composition: Deproteinized bovine bone mineral matrix (preserved micro- and macrostructure)
• Variant: creos™ xenogain collagen contains 10% porcine collagen
• Form factors: vial, syringe, bowl; collagen variant also in block form
• Indications: GBR and GTR, sinus augmentation, socket preservation
• Properties: osteoconductive, hydrophilic (fast rehydration), homogeneous particle size, interconnected macropores, long-term volume stability
• Biocompatibility: bovine proteins and lipids removed during processing