Visualization medical software

analysisdiagnosticpost-processing

Status & Intended use
Web-based post-processing platform offered for research use only. Investigational device; not CE marked and not FDA cleared. Presented as a research tool for quantitative analysis of fetal MRI data.

Overview
Cloud/web application for quantitative fetal MRI post-processing. Enables evaluation of fetal cardiac morphology, function and hemodynamics, and supports workflows for myocardial strain and 4D flow assessment. Integrates an advanced slice-to-volume reconstruction pipeline (auto-proc-SVRTK) from King’s College London to convert motion-corrupted 2D MR stacks into motion-compensated 3D volumes. Designed to complement Northh Medical smart-sync Doppler Ultrasound gating hardware.

Platform features and capabilities

• Slice-to-volume reconstruction (motion compensation) via the auto-proc-SVRTK pipeline (King’s College London).
• Generation of a single motion-corrected volumetric dataset from multiple 2D MR stacks.
• Processing available for brain, thorax (lungs) and body; outputs are downloadable for integration with external analysis or annotation software.
• Automated brain and lung volume segmentation algorithms integrated (work by Uus et al.).
• Automated multi-regional segmentation and parcellation without manual intervention.
• Workflows supporting myocardial strain analysis and 4D flow evaluation for fetal cardiac MRI.

Fetal Motion Correction
Reconstructs motion-corrupted 2D image stacks into motion-compensated 3D volumes to improve re-orientation in any imaging plane and reduce the need for repeated plane-specific acquisitions.

Volume Segmentation
Automated segmentation and multi-regional parcellation for brain and lungs enable automated volumetry and region delineation without manual segmentation effort.

Regions of interest & clinical value

• Brain: automated volumetry, re-orientation in any plane, and parcellation to support diagnostic assessment.
• Thorax / Lungs: multi-regional lung segmentation and accurate volume calculation for motion-corrupted acquisitions; supports anatomical tracking.
• Body: comprehensive 3D reconstructions to improve visualization of fetal body anatomy.

Research & Publications (selection)
Documentation references published research underlying integrated algorithms and methods. Notable items include:

• 2012 — Reconstruction of fetal brain MRI with intensity matching and complete outlier removal (M. Kuklisova-Murgasova et al.).
• Deformable slice-to-volume registration methods for motion correction in fetal body MRI and placenta (deformable SVR approaches).
• 2020 — Uus et al., automated 3D reconstruction and segmentation (IEEE Transactions on Medical Imaging).
• 2022 — Automated 3D reconstruction of the fetal thorax in standard atlas space for 21–36 weeks GA (Uus et al.).
• 2023 — BOUNTI: brain volumetry and automated parcellation for 3D fetal MRI (eLife).
• 2024 — Recent medRxiv and conference contributions on scanner-based real-time 3D slice-to-volume reconstruction and lung parcellation approaches.

Notes & limitations
The platform is investigational and intended for research use only. Not cleared for clinical diagnostic use (not CE marked / not FDA cleared). Presented as a software complement to Northh Medical smart-sync gating hardware and incorporates external academic algorithms for reconstruction and segmentation.

Technical specifications

• Form factor: Web-based platform (cloud/web application).
• Primary function: Motion correction (slice-to-volume reconstruction) of fetal 2D MR stacks into motion-compensated 3D volumes.
• Supported regions: Brain, Thorax (lungs), Body.
• Integrated algorithms: auto-proc-SVRTK (King’s College London) for slice-to-volume reconstruction; automated brain and lung segmentation algorithms (Uus et al. and collaborators).
• Output: Downloadable motion-corrected volumetric datasets suitable for further analysis/annotation in external software.
• Supported workflows: Myocardial strain analysis, 4D flow evaluation, automated volumetry and parcellation.
• Regulatory status: Investigational device; for research use only; not CE marked or FDA cleared.
• Designed complement: Compatible with Northh Medical smart-sync Doppler Ultrasound gating hardware.