Laboratory fiber photometry system R830

for researchneuroscienceneural circuit

Overview
The fiber photometry system enables optical recording of population neuronal activity in freely behaving animals using implanted multimode fibers and compact headstage-free implants. The platform supports long-term experiments with reduced surgical footprint, lightweight implants and efficient data management. It is compatible with GECIs (e.g., GCaMP), red-shifted indicators and neurotransmitter probes, and designed to integrate with behavioral paradigms for studies of region-specific and coordinated neural dynamics.

Advantages

• High sensitivity via dual-detector and time-division multiplexing (TDM) design
• Multichannel capability — supports simultaneous recording from up to 9 channels (model-dependent)
• Integrated data acquisition and analysis tools with visualization functions
• Flexible interfaces and event-marking for synchronization with behavioral or stimulation equipment

How the Fiber Photometry System Works
Genetically encoded calcium indicators (GECIs) change fluorescence with intracellular calcium transients, which correlate with neuronal activity. A two-wavelength GCaMP approach (isosbestic reference + calcium-dependent excitation) is used to reduce motion and autofluorescence artifacts: an isosbestic excitation captures calcium‑independent signal (reference) while a calcium-dependent excitation measures activity-related fluorescence. The system combines signals across fibers to assess coordinated activity across brain regions and during social or behavioral tasks.

Available Models
R830 Four-Color Multichannel Fiber Photometry System
Four excitation wavelengths (410 nm, 470 nm, 560 nm, 640 nm) for simultaneous detection of green, red and far-red indicators (e.g., GCaMP, dLight, RCaMP, jRGECO1a, HaloDA1.0).

R821 / FR-21 Tricolor Multichannel Fiber Photometry System
Configurable with 410 nm plus 470 nm or 560 nm excitation; 410 nm used as reference to reduce noise. Supports green and red indicators and neurotransmitter probes.

R811 / FR-11 Dual-Color Multichannel Fiber Photometry System
Provides 410 nm and 470 nm excitation for two-wavelength GCaMP recordings; compatible with standard optoelectronics and neurotransmitter probes.

R812 / FR-12 Dual-Color Multichannel Fiber Photometry System
Supports 410 nm and 560 nm excitation for red-shifted indicators and can record from multiple sites (configurations support up to 9 simultaneous sites where applicable).

Technical specifications

• Excitation wavelengths by model: R830: 410/470/560/640 nm; R821: 410/470/560 nm; R811: 410/470 nm; R812: 410/560 nm
• Two-wavelength GCaMP recording: 405 nm (isosbestic reference) + 470 nm (calcium-dependent)
• Detection: dual detectors with Time-Division Multiplexing for improved signal-to-noise
• Channels: up to 9 simultaneous recordings (model- and configuration-dependent)
• Supported indicators: GCaMP, dLight, RCaMP, jRGECO1a, HaloDA1.0 and various neurotransmitter probes
• Features: data acquisition/analysis, visualization, multiple interfaces, event marking and synchronization
• Applications: region-specific and coordinated neuronal population recordings in freely behaving animals; studies of behavior and social interaction correlates