The Whole-Body Exposure System is a commonly used experimental apparatus in toxicology, pharmacology, and environmental health sciences. It is designed to expose laboratory animals (such as mice, rats, guinea pigs, etc.) to controlled concentrations of test substances in gaseous, vapor, or aerosol form through natural respiratory pathways. Unlike the Nose-only Exposure System, which restricts exposure to the respiratory tract, the Whole-Body Exposure System allows the animals’ entire bodies (including skin and fur) to be exposed to the test environment.
1. Simulating Realistic Exposure Scenarios:
The Whole-Body Exposure System more accurately simulates real-world exposure conditions, such as air pollution, chemical spills, or aerosolized drug delivery. It enables the study of how pollutants enter the body through multiple pathways such as inhalation and dermal contact.
2. Comprehensive Analysis of Multiple Exposure Routes:
Inhaled substances can affect not only the respiratory system but also enter the bloodstream and reach other target organs (e.g., cardiovascular system, nervous system, liver, kidneys). Whole-body exposure provides a more complete assessment of the systemic toxicity of test substances.