LC chromatography column Shim-pack NovaCore C18-HB

for research and development

The Shim-pack NovaCore C18-HB core-shell columns are packed with an organic silica hybrid base material. Shim-pack NovaCore C18-HB offer a wider range of pH tolerance (pH 1 to 12) than columns packed with a conventional silica gel material, making them suitable for applications involving basic conditions that were previously difficult to accommodate. For fast analysis using a column packed with 2.6 µm particles, they can produce sharp peaks without a significant increase in pressure. By offering such characteristics, the Shim-pack NovaCore C18-HB serve as a revolutionary new Shim-pack series core-shell column that enables the analysis of a wide range of sample types. Suitable for a Wide pH Range from Acidic to Basic Many drugs and metabolites contain amine groups which can exhibit unstable retention times and peak shapes under acidic conditions. These compound types are often analyzed using an ion-pairing reagent or in basic conditions to improve reproducibility and peak shape. Unlike traditional silica-based columns with a limited pH range, typically 2 to 7.5, Shim-pack NovaCore C18-HB columns can be used across a wide pH range (1 to 12) due to their organic silica hybrid base material. This makes them especially suitable for developing methods for basic analysis, since many standard silica columns have an upper pH limit of 7.5. This graph shows that the NovaCore C18-HB has 2 – 3 times longer lifetime, measured as % loss of theoretical plates, under strongly basic conditions (pH 11.5), compared to traditional silica-based C18 columns.