Dissolution testing system CE 7smart Offline

flowpHfor tablets

Flow-through cell dissolution testing system to automatically collect samples. COLLECT – Collect dissolution testing samples in tubes or vials CONTROLLED – Controlled hydrodynamics OPEN – Open loop configuration with infinite sink conditions, automated pH changes CLOSED – Closed loop configuration with fixed volumes (15 - 4000 mL) for compendial low-volume dissolution IVIVC – Simplified in-vitro / in-vivo correlation with open loop configuration ADAPT – Test APIs, oral, topical and parenteral dosage forms reproducibly CLEAN – Automated cleaning procedure Collecting dissolution testing samples offline is the simplest way to automate a dissolution test. To take the sample from the constant flow, a splitting valve is used. The liquid is pumped with the CP pump, on the way to the collecting tube / vial the sample is filtered, through a circular filter located in the flow-through cell head. The samples are stored in the auto sampler C613 or C615. In this process the sample is always treated the same way, this makes it most efficient. From API to novel dosage forms Dissolution testing is a supra-indicator of parameters monitored during the manufacturing of a dosage form. The CE 7smart apparatus 4 widens the design of experiment being the only compendial dissolution instrument allowing a reproducible testing of APIs, intermediates and final dosage forms. The CE 7smart gives relevant information from pre-formulation and characterization to IPC and QC testing. Biorelevant methods Envisioned to mimic in-vivo conditions more accurately than beaker methods, the Flow-Through Cell technique was born to ambitiously push dissolution testing borders.