Automatic dissolution tester CE 7smart

continuousfor the pharmaceutical industryfor in-vitro drug release

Overview Flow-through cell dissolution testing system for controlled-release and immediate-release dosage forms with integrated online UV‑Vis photometric analysis and optional offline autosampler collection. Supports combinations with different photospectrometer types and flexible workflows for real-time monitoring or manual confirmatory analysis.

Key benefits

• COLLECT OR ANALYZE – Obtain real‑time dissolution profiles via online UV‑Vis and/or collect the same samples offline in an autosampler for alternative or confirmatory analytical finishes.
• ADAPT – Reproducible testing across APIs, oral, topical, parenteral and subcutaneous injectable formulations.
• PROGRAM – Centralized method and specification management in a validated platform using WinSOTAX®plus.
• TEST – Full control of fractions, time points, flow rates and media changes for complex dissolution protocols.
• RECORD – Audit trail, user rights, validated data handling and comprehensive reporting ensure traceability and compliance.

Highlights Ready, set, disso The CE 7smart enables combined online UV‑Vis measurement and offline sample collection. When backup sampling or alternate analytical workflows are required, measured aliquots can be directed to the autosampler after photometric assessment.

From API to novel dosage forms CE 7smart expands design‑of‑experiment capabilities and is the compendial solution for reproducible testing of APIs, intermediates and finished dosage forms. Applicable throughout pre‑formulation, characterization, IPC, QC and R&D phases.

Biorelevant methods The Flow‑Through Cell technique is compatible with biorelevant media (level 0–3) and allows on‑the‑fly pH adjustments for extended or delayed release studies. Suitable for poorly soluble compounds (BCS class II and IV).

Volume flexibility Supports open and closed loop configurations with media volumes from 50 to 5000 mL while maintaining consistent hydrodynamic conditions and reproducible dosage form positioning.

Assessing subcutaneous injectable drug release BioJect™ technology extends flow‑through testing to subcutaneous injectables and peptide formulations. The BioJect cell (22.6 mm diameter) includes a hydrogel (agarose) reservoir to control pore size and diffusion properties.

Modules

• WinSOTAX®plus – Validated dissolution software for method management, data capture and reporting.

Technical specifications

• Model: CE 7smart (flow‑through cell dissolution tester).
• Integrated analysis: online UV‑Vis (photometric) with option for offline autosampler collection.
• Sample handling: measure online and optionally collect measured aliquots offline for alternate analytical finishes.
• Applicable dosage forms: APIs, oral, topical, parenteral and subcutaneous injectables (via BioJect™).
• BioJect™ cell diameter: 22.6 mm; hydrogel (agarose) reservoir for controlled diffusion.
• Media volume range: 50–5000 mL (open and closed loop configurations supported).
• Compatibility: biorelevant media levels 0–3; suitable for BCS class II and IV compounds.
• Method programming: full control over fractions, time points, flow rates and media changes.
• Data management and compliance: WinSOTAX®plus; user rights, audit trail and validated reporting.
• Typical applications: pre‑formulation, characterization, IPC, QC and R&D dissolution testing.