Automated sample preparation system JetX™ MultiFlow

automaticfully automatedfor sample preparation

Overview
JetX™ MultiFlow is an automated sample preparation system for high-throughput extraction, sampling, filtration and dilution prior to U/HPLC analysis. It uses patented JetX™ technology and integrated media reservoirs to generate homogeneous stock solutions from tablets, capsules and other dosage forms.

Key Benefits

• Short cycle times: supports simultaneous extraction of 5 samples and throughput up to 120 samples per shift.
• High capacity: unattended continuous sequences processing up to 30 samples.
• Increased productivity: up to ~4× sample throughput versus a single analyst.
• Fully automated workflow: extraction, sampling, fine filtration and dilution integrated for U/HPLC readiness.
• Validated cleaning: automatic self-cleaning of fluidic paths to minimize carry‑over.
• Data integrity: AutoDI™ documents all preparation steps for full traceability and report export.
• Rapid method setup: create new methods in under 3 minutes or load pre-programmed methods.

Highlights & Features
Rapid Extraction – The Heart of JetX™
Patented JetX™ technology extracts APIs by exposing dosage forms to a continuous jet of media inside an extraction cell. Flow rates up to 1´7000 mL/min promote rapid disintegration or targeted erosion, with recirculation and vortex mixing in media reservoirs until extraction is complete.

Unattended Operation with JetMags™
JetX™ MultiFlow performs extractions on five samples per cycle; with JetMags™ it can process 30 samples in one unattended continuous sequence, including automated filling, extraction, dilution and self-cleaning.

Homogeneous Stock Solution with Media Reservoirs
Media reservoirs employ flow-through rinse-down filling with gravimetric confirmation and integrated magnetic stirring to maintain homogeneous stock solutions throughout the process.

Sampling and Fine Filtration for U/HPLC Analysis
Stock solution samples are taken automatically from all reservoirs. High-performance piston pumps enable fine filtration down to 0.2 µm using standard syringe filters; filtered samples are deposited in capped LC vials for downstream analysis.

Precise Dilution and Seamless Transfer to U/HPLC
An integrated high-precision micro-dosing pump and single-sequential needle transfer precise volumes to standard LC vials and adds dilution media, supporting dilution ratios up to 1:100 and compatibility with standard vial plates/autosamplers.

Validated Cleaning
All fluidic paths undergo automatic validated cleaning after each extraction to ensure reproducibility and reduce contamination risk.

AutoDI™ – Audit-ready Documentation
AutoDI™ records every preparation step and exports preparation reports suitable for lab notebooks, LIMS or other data-management systems to ensure audit-ready traceability.

Applications & Services
Intended for tablets, capsules and other solid dosage forms requiring content uniformity and high-throughput sample preparation. SOTAX Pharma Services can perform speed and feasibility studies to compare JetX™ extraction with existing manual methods in a GMP-compliant environment.

Technical specifications

• Product family / model: JetX™ MultiFlow
• Manufacturer / brand: SOTAX
• Simultaneous extraction: 5 samples per extraction cycle (JetMags™)
• Unattended sequence capacity: up to 30 samples in one continuous automated sequence
• Throughput claim: up to 120 samples per shift (short cycle times)
• Relative throughput: ~4× samples vs a single lab analyst
• Flow rate: Flow rates up to 1´7000 mL/min (as quoted on product page)
• Media reservoirs: automatic filling with gravimetric confirmation, flow-through rinse-down, integrated magnetic stirring
• Sampling: simultaneous sampling from all media reservoirs
• Filtration: fine filtration down to 0.2 µm using standard syringe filters
• Dilution: high-precision micro-dosing pump enabling up to 1:100 dilution ratios
• Transfer: sequential single-needle transfer to standard LC vials; compatible with standard vial plates/autosamplers
• Cleaning: fully automated self-cleaning / validated cleaning of fluidic paths after each extraction
• Automation: fully automated workflow including filling, extraction, dilution, filtration and cleaning
• Data integrity: AutoDI™ documents and exports preparation reports for traceability
• Intended analysis: preparation for U/HPLC (U/HPLC-compatible sampling and dilution)