Automated sample preparation system JetX™ SingleFlow

for sample preparationby extractionhigh-speed

Product overview
The JetX™ SingleFlow is a development tool for rapid sample preparation in content uniformity (CU) testing workflows. It applies patented JetX™ continuous jet extraction to extract active pharmaceutical ingredients (APIs) from solid and semi-solid dosage forms. Media are circulated from an integrated reservoir through an extraction cell and back, delivering homogenous stock solutions and enabling fast single extractions in R&D with automated self-cleaning.

Key benefits

• EXPLORE – Development tool for scientific exploration of sample preparation methods for content uniformity (CU) testing
• DEVELOP – Investigate the impact of method parameter changes on core extraction performance
• FAST – Perform single extractions rapidly in R&D with automated self-cleaning
• EXTRACTION – Powerful jet extraction for tablets, capsules, semi-solids and other dosage forms
• SELF-CLEANING – Automatic cleaning of flasks, bottles and fluidic paths to reduce manual downtime
• EASY – Intuitive JetPilot™ interface for quick adjustment of extraction parameters
• REPORT – Pump and run data recording with DataLink™ export and PDF report generation

Highlights

• Patented JetX™ continuous jet extraction: a focused, continuous medium jet subjects dosage forms to controlled erosion and disintegration
• Homogeneous stock solutions: integrated reservoir recirculation through the extraction cell with magnetic stirring ensures sample homogeneity
• High throughput capability: maximum flow rate up to 1,700 mL/min through the extraction cell; aqueous media can be heated up to 60°C to accelerate disintegration
• Automated self-cleaning: completes cleaning cycle after each extraction run to avoid time-consuming manual cleaning
• JetPilot™ user interface with AutoDI™: create or load methods, automatic tracking for traceability and compliance; DataLink™ enables data export and audit trails
• Proven comparability: speed trials demonstrate result comparability to support ROI and method transfer studies

Applications

• Tablets
• Capsules
• Semi-solids
• Other dosage forms requiring jet extraction for sample preparation

Technical specifications

• Extraction technology: patented JetX™ continuous jet extraction
• Media circulation: integrated reservoir with recirculation through the extraction cell
• Integrated magnetic stirrer: continuous mixing of stock solution to ensure homogeneity
• Maximum flow rate: up to 1,700 mL/min through the extraction cell
• Temperature control: controlled heating up to 60°C for aqueous media to support disintegration/erosion
• Operation: JetPilot™ user interface with AutoDI™ for rapid method setup and pre-programmed methods
• Data & reporting: automatic tracking for traceability, DataLink™ export, PDF report generation and pump data logging
• Cleaning: automated self-cleaning of fluidic paths and reservoir after runs
• Intended use: rapid single extractions for R&D and method development in content uniformity testing workflows