Ion mobility spectrometer timsTOF SCP

masstransferfor research

The timsTOF SCP for quantitative single cell biology research with unbiased, deep single-cell 4D-Proteomics™, immunopeptidomics, epiproteomics and PTM analysis to complement scRNA-seq. Expanding the horizons of single cell research. Ultra-High Sensitivity Ground-breaking design of a novel ion source geometry for up to five times higher ion transfer and ultra-high robustness. Data Completeness Data independent acquisition–parallel accumulation serial fragmentation (dia-PASEF) pushes the limits of reproducible quantification to pave the way to study cell heterogeneity at scale. Acquisition Speed High acquisition speed combined with dia-PASEF sensitivity enables analysis at short liquid chromatography (LC) runs without chromatographic dilution of very low sample amounts. Robustness Double orthogonal reflection into trapped ion mobility spectrometry (TIMS) enables routine operation over thousands of samples without instrument cleaning. Redefining single cell proteomics Advanced ion optics and PASEF to investigate cell heterogeneity and biology from a single cell Mass spectrometric proteomics has become a staple of modern research in understanding biological function and disease mechanisms. Healthy or diseased tissues that seem homogenous are composed of cells with a variety of different proteomes. The challenge of deciphering the proteomes in each single cell – the cell heterogeneity – holds the key to fully understanding its function. The timsTOF SCP offers a radically improved ion source concept. Combined with parallel accumulation serial fragmentation (PASEF®) acquisition methods,