Genetic mutation test kit Xpert ® NPM1

for AMLgeneticmyeloid leukemia

Fast, sensitive on-demand monitoring of NPM1 mutant mRNA transcripts in Acute Myeloid Leukemia patients The Need Acute Myeloid Leukemia (AML) is the most common acute leukemia in adults.1 The Nucleophosmin (NPM1) mutation is one of the most common genetic abnormalities in AML, accounting for about 30% of cases.2,3 Established international organizations recommend periodic molecular assessment by quantitative PCR for monitoring NPM1 mutations in AML patients.4-6 No international scale is established for the quantification of the NPM1 mutant transcript for AML monitoring posing a challenge for quantitative monitoring. The Solution The Xpert NPM1 Mutation test is an automated test for quantifying the amount of mutant NPM1 mRNA transcripts (types A, B, and D in exon 12) as a ratio of NPM1 Mutation/ABL1.7 Proprietary in-house RNA control materials are used to calibrate and standardize each lot of the Xpert NPM1 Mutation.8 The Impact Timely monitoring ensures measurement of treatment response and detection of potential relapse.6 Quickly classify AML subtype (NPM1-mutant vs NPM1 wild type) to guide clinical decisions and prognosis.4 Minimize challenges associated with result interpretation with a fast, easy-to-use, on-demand test and standardized reports.8