High-throughput synthesis platform ISYNTH CATSCREEN 96

robotized

Overview
The patented overhead gravimetric dispensing/dosing technology combined with a fully automated SBS/well‑plate pressure block and intuitive software enables accelerated, standardized and digitalized catalyst synthesis and screening in flexible well‑plate formats (e.g. 12×20 mL, 24×8 mL, 48×2 mL, 96×1 mL total volume glass vials). The system supports unattended catalyst preparation, formation/assembly and screening at ambient and elevated pressures in disposable glass vials/reactors with downstream work‑up and integrated analysis.

Workflow
ISYNTH CATSCREEN 96
Migrated workflow: ISYNTH CATSCREEN 96

• Add catalyst
• Add solvent
• Add solid or liquid into vial on MTP
• Transfer MTP to pressure block
• Apply pressure up to screening conditions
• Shake and heat (CATSCREEN)
• Transfer MTP to tray
• Work‑up (e.g. filtration, sampling)

Benefits

• Fully automated, integrated catalyst preparation and screening at ambient and elevated pressure in well‑plate format (up to 100 bar safety pressure and 250°C jacket temperature).
• Disposable, high‑precision glass reactor arrays compatible with SBS/well‑plate standards (12×20 mL, 24×8 mL, 48×2 mL, 96×1 mL).
• Unique automated well‑plate pressure screening block for reactive gas chemistries (CATSCREEN) and superheated chemistries (SPEEDCHEM).
• Automated work‑up options: L/L extraction, filtration, solid‑phase extraction, crystallization and drying.
• Proprietary robotic tool exchange for flexible automation.
• Gravimetric solid handling from μg to g and liquid handling from μL to mL (mg to g).
• Chemistry‑proven liquid handling with pH control, filtration and heated needle extension.
• High throughput: parallel reactions (12 / 24 / 48 / 96 per run).
• Integrated sampling and analytics: benchtop online NMR, HPLC (MS), UPLC (MS), GC (MS), UV‑VIS, NIR/MIR, DLS measurement cell.
• Optional ventilated, conditioned hood or glove‑box integration for sensitive, low‑temperature chemistry.
• AUTOSUITE software for drag & drop experiment design, LIMS/ELN connectivity and AI/ML closed‑loop workflows.
• Optional integrated online benchtop NMR with flow cell or offline sampling (5 mm tubes); permanent magnet—no liquid nitrogen or helium required.

Technical specifications

• Supported well‑plate formats and disposable glass vial arrays: 12×20 mL, 24×8 mL, 48×2 mL, 96×1 mL (total vial volumes).
• Pressure capability: up to 100 bar safety pressure in 96‑well pressure block.
• Jacket temperature capability: up to 250°C.
• Gravimetric solid handling range: micrograms (μg) to grams (g).
• Gravimetric liquid handling range: microliters (μL) to milliliters (mL), mg to g.
• Automated work‑up options: liquid‑liquid extraction, filtration, solid‑phase extraction, crystallization, drying.
• Integrated analytics options: benchtop online NMR, HPLC (MS), UPLC (MS), GC (MS), UV‑VIS, NIR/MIR, DLS measurement cell.
• Software: AUTOSUITE for experiment design, execution and data integration; supports LIMS/ELN and AI/ML closed‑loop workflows.
• Proprietary robotic tool exchange for flexible automation.
• Optional ventilated/conditioned hood or glove‑box integration for sensitive chemistries.