Microwave synthesis platform ISYNTH SWAVE

robotized

Overview
High-throughput microwave-assisted library synthesis (small molecules, polymers, porous materials, cathode materials) combined with Chemspeed’s exchangeable robotic tools for gravimetric liquid handling, gravimetric solid dispensing, capping, de-capping, crimping and gripping, integrated with microwave technology for automated parallel reaction execution and sample processing.

Summary
Automated microwave-assisted synthesis and integrated sample treatment. Complete, configurable workflow enabling reaction setup, microwave synthesis, multistep synthesis, work-up and analysis for high-throughput screening and library generation.

Workflow (example steps)

• Gravimetric dispensing (solid)
• Volumetric dispensing (liquid)
• Capping and crimping / de-capping
• Transfer to microwave synthesizer
• Microwave irradiation
• Addition of reagents for further steps / multistep synthesis
• Work-up: SPE, filtration, evaporation, L/L extraction, crystallization, drying, online/offline analysis

Benefits

• High-throughput microwave-assisted synthesis and integrated sample treatment.
• Fully automated orchestration: reaction preparation, synthesis, work-up, analysis and output to storage vials for μL and mL screening in solid- and liquid-phase.
• End-to-end reagent handling: preparation, capping/crimping/gripping, multistep synthesis, work-up, automated transfer and analytics.
• Work-up capabilities including evaporation, liquid–liquid extraction, filtration, solid-phase extraction (SPE), crystallization and drying.
• Proprietary robotic tool exchange for flexible workflows.
• Gravimetric solid handling from μg to g; gravimetric liquid handling from μL to mL and mg to g.
• Chemistry-proven liquid handling with pH control, filtration and heated needle extension options.
• Throughput configurations: e.g. 24 / 48 / 96 parallel reactions per run.
• Integrated sampling and analytical options: benchtop online NMR, HPLC-(MS), UPLC-(MS), GC-(MS), UV‑VIS, NIR/MIR, DLS measurement cell.
• Ventilated hood for safe and conditioned operation.
• AUTOSUITE SOFTWARE - drag & drop experiment design with easy interface (custom Python device support) and integration to LIMS/ELN, data analysis and AI/ML closed-loop workflows.
• Optional integrated online benchtop NMR: 80 MHz Fourier RxnLite NMR device with sample injection port; software for advanced chemical profiling and hardware integration; supports H/F/C/P/Si/B nuclei, 1D and 2D spectra; online acquisition via flow cell or offline via standard 5 mm tubes; permanent magnet (no liquid nitrogen or helium required).

Technical specifications

• Model / Workflow name: ISYNTH SWAVE
• Automation: fully automated reaction preparation, synthesis, work-up and analytics orchestration
• Robotic toolset: exchangeable tools for gravimetric liquid handling, gravimetric solid dispensing, capping, de-capping, crimping, gripping
• Solid handling range: micrograms (μg) to grams (g) (gravimetric)
• Liquid handling range: microliters (μL) to milliliters (mL); mg to g (gravimetric)
• Throughput: parallel reaction configurations (examples: 24 / 48 / 96 wells per run)
• Microwave integration: transfer to microwave synthesizer and microwave irradiation capability
• Work-up capabilities: evaporation, liquid–liquid extraction, filtration, solid-phase extraction (SPE), crystallization, drying
• Integrated analytics: benchtop online NMR (optional), HPLC-MS, UPLC-MS, GC-MS, UV‑VIS, NIR / MIR, DLS measurement cell
• Software: AUTOSUITE for drag & drop experiment design; supports integration with LIMS/ELN and AI/ML closed-loop workflows
• Safety/environment: ventilated hood for conditioned operation