Hemophilia A rapid diagnostic test GTHapScreen® F8

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The GTHapScreen F8 kit is developed to detect carrier and/or affected sample for Factor VIII deficiency or commonly known as Hemophilia A disorder. The kit functions on the principle based on STR markers and QF PCR technique to detect carrier or to be patient by linkage analysis. Use of STR markers makes prenatal diagnosis more accurate and reliable. Kit components include multiplex PCR primers which are designed from F8 gene. This gene is used commonly in carrier detection and prenatal diagnosis of Factor VIII deficiency. STR markers designed from 5 regions that covers the upstream and downstream of the F8 gene. This kit is optimised to use DNA samples purified from blood, amniotic fluid, and chorionic villus (CVS). Along with Factor VIII deficiency detection the GTHapScreen F8 kit includes autosomal STR markers for Chromosome 21, 18, 13, X and Y. These markers provide extra advantages along with detection of this disorder. Features Aids carrier detection and prenatal diagnosis Rules out/in sample authenticity, maternal cell contamination It aids gonadal mosaicism detection Chromosomal aneuploidy detection Determination of fetus’ sex