Bovine Viral Diarrhea Virus (BVDV) is a virus that severely affects herd health and performance. It is the causative agent of bovine viral diarrhea (BVD) and mucocutaneous disease (MD), and is widespread in cattle herds worldwide.
1.Clinical symptoms
Symptoms of BVDV infection vary depending on the virulence of the virus strain, age of infection and immune status. The main clinical signs include:
Acute infection
Fever: mild to moderate fever.
Diarrhea: watery diarrhea, sometimes accompanied by bleeding.
Respiratory symptoms: cough, nasal discharge, dyspnea.
Immunosuppression: leading to an increased risk of secondary infections.
Chronic infections
Growth retardation: slow growth in infected cattle.
Reproductive problems: including abortion, stillbirths, sterility and fetal malformations.
Hemorrhagic syndrome: severe cases of spontaneous hemorrhage, manifested by bleeding from the gums, intestines, and skin.
Mucocutaneous disease (MD)
Highly lethal: rapid onset and high morbidity and mortality.
Oral ulcers: severe oral, esophageal, and intestinal ulcers.
Wasting and dehydration: rapid wasting and dehydration, often death within a few days.
2.Transmission pathway
Direct contact: spread through saliva, nasal fluid, feces and urine of infected cattle.
Indirect transmission: through contaminated feed, water, equipment and vehicles.
Vertical transmission: the infected cow passes the virus to the fetus through the placenta, resulting in fetal infection or stillbirth.
Semen transmission: transmitted through the semen of infected bulls, resulting in infection of cows.