PET laboratory cyclotron Cyclone® KEY

compact

Overview
Cyclone® KEY is a compact, fully automated clinical cyclotron engineered to accelerate protons to 9.2 MeV for efficient multi‑isotope PET radioisotope production. Its reduced footprint and flexible installation options make it suitable for small and medium hospitals and compact radiopharmacies.

Key product information
Cyclone® KEY supports production of 18F, 13N and gaseous 11C with liquid and gas target compatibility. The system is designed for reliable operation, simplified workflows and straightforward maintenance. Its compact configuration can reduce the (c)GMP radiopharmacy footprint to approximately 80 m² at facility level.

Benefits

• Very small footprint compared with clinical cyclotrons of comparable performance.
• Fully automated operation to simplify isotope production workflows and reduce manual interventions.
• Supports multiple target types (liquid and gas) and up to three targets via a single exit port.
• High production capability with up to 100 µA beam current for significant radiotracer yields.
• Flexible installation: conventional concrete vault or self‑shielded configuration.
• Optimized for PET radiotracer production for oncology, neurology and cardiology clinical applications.

Performance highlights

• Proton energy: 9.2 MeV.
• Production current (beam): up to 100 µA.
• Exit ports: 1 exit (supports up to 3 targets).
• Production output: example up to 3 Ci in 2 hours (18F basis).
• FDG doses: up to ~23 FDG doses per run from 3 Ci (111 GBq) end of beam at 70% chemistry yield; higher counts (e.g. ~30 doses in 2 hours) achievable with optimized Synthera® chemistry configurations.

Installation & footprint
The Cyclone® KEY provides dimensions and installation options suitable for constrained environments and compact GMP radiopharmacies.

Vault dimensions
3.15 x 3.15 x 2.2 m

Cyclotron dimensions
1.5 x 1.4 x 1.35 m

Applications & reliability
Cyclone® KEY enables in‑house production of PET radioisotopes at small and medium hospitals and radiopharmacies, supporting clinical imaging in oncology, neurology and cardiology. The product leverages IBA RadioPharma Solutions experience for serviceability and consistent performance.

Additional notes
The system is compatible with Synthera® radiochemistry platforms for integrated end‑to‑end radiopharmaceutical production and can be integrated into compact GMP radiopharmacy layouts to limit capital expenditure.

Technical specifications

• Commercial name: Cyclone® KEY
• Brand: IBA RadioPharma Solutions
• Proton energy: 9.2 MeV
• Production current (beam): up to 100 µA
• Targets supported: Liquid, gas
• Exit ports: 1 exit (up to 3 targets)
• Production output: Up to 3 Ci in 2 hours (example for 18F)
• FDG doses per run: Up to ~23 doses (based on 3 Ci end of beam and 70% chemistry yield); up to ~30 doses with optimized chemistry in 2 hours
• Vault dimensions: 3.15 x 3.15 x 2.2 m
• Cyclotron dimensions: 1.5 x 1.4 x 1.35 m
• Installation options: conventional concrete vault or self‑shielded configuration
• Intended applications: PET imaging radiotracers for oncology, neurology, cardiology