PET laboratory cyclotron Cyclone® KIUBE

Overview
Cyclone® KIUBE is an internal-source PET cyclotron engineered for industrial, cGMP-capable isotope production. It combines compact footprint, low resource usage and an upgrade path to meet evolving production needs, enabling localized manufacturing of PET isotopes and radiometals for clinical and commercial radiopharmacy.

Applications

• PET imaging radionuclide production and radiopharmaceutical manufacturing

Supported isotopes

• 18F
• 68Ga
• 89Zr
• 64Cu
• 13N
• 11C
• 15O
• 123I
• 124I

Key features

• Internal-source design for PET isotope production
• Compact footprint with options for self-shielding vaults
• Energy-efficient operation with reduced water consumption
• Upgradeable beam current: 100 µA → 150 µA → 180 µA → 300 µA (on-target)
• Up to 8 fully independent exit ports
• Up to 2 beam lines for concurrent target stations
• Production output: up to 38 Ci in a 2-hour run (based on 18F)
• FDG doses: up to 380 doses in a 2-hour run (based on 18F)
• Twin proton sources and redundant subsystems for operational reliability (patent EP2196073B1)
• Supports solid, liquid and gas targets

Performance & benefits

• Cost-efficient PET production solution combining high yield with compact installation needs
• Designed for industrial-scale and high-activity production to meet local demand for clinical and commercial isotopes
• Modular upgrade path allows capacity increases as requirements evolve

Technical specifications

• Energy: 18 MeV
• Vault dimensions: 3.8 × 3.8 × 2.5 m (standard) or 6 × 7 × 3 m with self-shielding
• Cyclotron dimensions: 1.9 × 1.9 × 1.8 m
• Target types: Solid, liquid, gas
• Production power / beam current (upgradeable): 100 µA → 150 µA → 180 µA → 300 µA (on-target)
• Exit ports: Up to 8 exits, fully independent
• Beam lines: Up to 2 beam lines
• Production output: Up to 38 Ci in a 2-hour run (based on 18F)
• FDG doses: Up to 380 doses in a 2-hour run (based on 18F)
• Reliability: Twin-proton sources and redundant subsystems (patent EP2196073B1)
• Designed for internal-source PET cyclotron applications and industrial, cGMP-capable isotope production