Fully automatic cell imaging system CytoInsight GSL

for researchfor karyotypingfor immunofluorescence

Overview
The CytoInsight GSL automated image analysis and case management system is a comprehensive Cytogenomics solution that improves quality and turnaround time from acquisition to analysis while reducing hands-on time at every step in the process. The platform supports brightfield and fluorescence image analysis, unlimited scanning for walk-away operation, expanded system flexibility, and enhanced cybersecurity features.

Key Capabilities

• Automated image analysis and case management from prepared slide to report and back
• Support for both brightfield and fluorescence microscopy
• Unlimited scan capacity with hot-swapping of slide trays for continuous scanning
• Mixed batch scanning: combined sessions for karyotyping, interphase spot scoring for FISH, and tissue FISH samples
• Flexible configurations (scanning stations, capture stations, review stations) to match applications, throughput, and networking requirements
• On-screen analysis to improve ergonomics and remove the need for darkroom workflows
• Remote access option for analysis and review, enabling geographic collaboration and director review

Product Features (detailed)

• Platform enables expansion with fully automated scanning system, capture stations, and review stations
• Mixed batch scanning for combined karyotyping, interphase spot scoring (FISH), and tissue FISH
• Unlimited scan capacity with hot swapping feature; pause current batch and swap individual slide trays
• Flexible configurations with increasing automation levels to optimize technical resources
• Custom user settings for break-apart, enumeration, and fusion assays
• Scanning, capture, analysis, and reporting modules for brightfield and FISH, including: karyotyping; automated/manual spot counting for cellular FISH; tissue FISH; flexible karyotyping (non-human species); Karyotype CGH; M-FISH; multi-session scoring; integrated flexible reporting; remote access
• 12 megapixel CMOS camera for high-resolution images and rapid image processing
• Robust high-speed data transfer with solid state drive (SSD)
• Motorized Leica DM6 B microscope integration for flexible, intelligent automation
• Case tracking and statistics: automatic tracking of analyzed cells, digital record of counts/results, progress tracking per class, case statistics for workload and quality management
• Image export functionality for use with automated karyotyping; chromosome counting/numbering, centromere identification, segmentation, and classification into karyogram

Software and Cybersecurity

• Compatibility with Windows 11 for increased cybersecurity
• User configuration and logging features
• Administrator-controlled access for selected users and functions
• Remote access solution available for brightfield and fluorescence analysis cases to support distributed review and collaboration

Reagents / Consumables
Kreatech FISH Probes: By combining REPEAT-FREE technology with Kreatech Diagnostics proprietary ULS labeling method, Kreatech probes deliver enhanced FISH probe performance. REPEAT-FREE technology removes repetitive elements via subtractive hybridization to improve specific binding kinetics and eliminate the need for blocking DNA. ULS labeling provides homogeneous and consistent fluorescent dye labeling.

Product Specification
Specification — Description
GSL 120 Capacity — 120-slide batch capacity
GSL 10 Capacity — 10-slide batch capacity
Camera Port — Fixed 1x C-mount with no optics
Nominal Input Voltage — 120V / 230V AC (auto sensing)
Mains Supply — +/- 10% Rated Voltage
Input Frequency — 50 Hz +/- 3 Hz (auto sensing)
Noise Emission — <60 dBA normal operation
Storage Conditions — Temperature: -15° to 45°C (5° to 113°F)
Storage Conditions — Humidity: 20-90% non-condensing (38.7°C)
Operation (General) — Indoor Use
Operation (General) — Ambient Temperature: 15° to 35°C (59° to 95°F)
Operation (General) — Humidity: 20-70% non-condensing; Maximum relative humidity: 70% for temperatures up to 36°C (96.8°F)
Operation (GSL scanning) — Optimal temperature: 20° to 25°C (68° to 77°F).

Configurations (summary)

• Scanning Station with GSL120 Automated Slide Loader: CytoInsight GSL workstation (software and protection key), computer with Windows OS, monitor, UPS, 12 MP CMOS camera, Leica DM6 B automated microscope with motorized XY stage and automated oiler, barcode reader, GSL 120 automated slide loader (120 slides)
• Scanning Station with GSL10 Automated Slide Loader: same workstation components with GSL 10 loader (10 slides)
• Capture Station with Leica DM6 B Microscope: workstation, 12 MP camera, Leica DM6 B with mechanical XY stage, Xylis LED lamp for FISH station
• Capture Station (without Microscope): workstation, 12 MP camera, optional Xylis LED lamp
• Review Station: CytoInsight GSL software and protection key, computer with Windows OS, monitor, UPS

Disclaimer
For Research Use Only. Not for use in diagnostic procedures.

Specifications / Technical characteristics

• Model / Series: CytoInsight GSL
• GSL 120 batch capacity: 120 slides
• GSL 10 batch capacity: 10 slides
• Camera: 12 megapixel CMOS camera (high-resolution)
• Camera port: Fixed 1x C-mount (no optics)
• Microscope: Compatible with Leica DM6 B (motorized XY stage for scanning stations; mechanical XY for capture)
• Automated features: automated oiler, automated slide loader (GSL 10 or GSL 120), barcode reader, hot-swap slide tray capability
• Storage temperature range: -15° to 45°C (5° to 113°F)
• Operational ambient temperature: 15° to 35°C (general); optimal 20° to 25°C for GSL scanning
• Humidity: storage 20-90% non-condensing; operation 20-70% non-condensing (max 70% up to 36°C)
• Power: Nominal input voltage 120V / 230V AC (auto sensing); input frequency 50 Hz +/- 3 Hz (auto sensing); mains supply tolerance +/-10%
• Noise emission: <60 dBA during normal operation
• Data storage/transfer: SSD for high-speed data transfer
• Software: CytoInsight GSL application with software protection key; Windows OS compatible (Windows 11 supported)