Optical microscope Viventis Deep

for life sciences applicationsfor cell culture monitoringfor research

Overview
The Viventis Deep light-sheet microscope combines dual-view detection and flexible sample handling to image live and cleared samples across large spatial scales. It supports multi-well and multi-position workflows and user-replaceable detection optics to switch between live-cell and cleared-sample configurations.

Explore life in depth

• Deep volumetric imaging from single cells to tissues and small organisms with enhanced spatio-temporal resolution.
• Patented dual illumination and dual-view detection for improved volumetric detail and isotropic information.
• Multi-position imaging and an open-top sample holder for flexible access and high-throughput experiment layouts.

Explore life events with long-term imaging
Gentle light-sheet illumination enables rapid volumetric acquisition while minimizing photodamage, supporting long-term time-lapse experiments. The system integrates with an advanced incubation solution and permits media exchange during experiments; an optional photomanipulation arm enables perturbation studies during time-lapse.

Explore live and cleared samples flexibly
User-replaceable detection optics allow switching between live-sample and cleared-sample modes. The cleared-sample module accepts a range of clearing media and refractive indices and supports samples from hundreds of micrometers up to approximately 9 × 6 × 6 mm. Tiling, stitching and computational clearing preserve image quality across large, scattering samples.

Key capabilities

• Dual illumination and dual-view detection for increased spatio-temporal resolution.
• Multi-well and multi-position capability for high-throughput or multi-sample experiments.
• Open-top sample holder for easy sample access and handling.
• User-replaceable detection optics to switch between live and cleared-sample configurations.
• Computational clearing, tiling and stitching for large-volume imaging of scattering samples.
• Gentle light-sheet illumination to minimize light dose and preserve viability in long-term imaging.
• Advanced incubation solution with easy media exchange during experiments.
• Optional photomanipulation arm for perturbation experiments during time-lapse.

Enabling your success with workflow support

• Global Leica service and application experts to support installation and workflows.
• Leica training program with multi-level factory certification.
• Leica logistics and regional hubs for genuine parts and fast support.
• Leica OneCall for expert assistance on operations and applications.

Technical specifications

• Commercial designation: Viventis Deep (system family name)
• Imaging modes: Live-cell volumetric imaging, time-lapse, z-stack, cleared-sample imaging
• Illumination: Gentle light-sheet (dual illumination option)
• Detection: Dual-view detection; user-replaceable detection optics for live vs cleared samples
• Sample holder: Open-top sample holder; supports multi-well and multi-position experiments
• Cleared-sample module: Accommodates diverse clearing media and refractive indices
• Supported sample size (cleared module): from hundreds of micrometers up to approximately 9 x 6 x 6 mm
• Computational features: Computational clearing, tiling and stitching for large-volume imaging
• Environmental control: Advanced incubation solution with capability for media exchange during running experiments
• Optional add-ons: Photomanipulation arm (optional) for perturbation during time-lapse
• Primary applications: Organoids, developmental models (e.g., zebrafish), live and cleared large tissue imaging, long-term live-cell experiments