Progesterone reagent kit 0727110-CF

serumplasmaclinical

The 17αOHP Coated Tube RIA Kit is intended for the measurement of 17α-hydroxyprogesterone in unextracted serum or plasma of adults and children. Kits are manufactured once per month and have an 8 week shelf life. Product Description The 17αOHP Coated Tube RIA Kit is intended for the measurement of 17α-hydroxyprogesterone in unextracted serum or plasma of adults and children. The steroid 17α-hydroxyprogesterone (17αOHP) is produced by both the adrenal cortex and gonads. Even though 17αOHP has relatively little progestational activity, it is of intense clinical interest because it is the immediate precursor to 11-desoxycortisol (Cpd-S). Because Cpd-S is produced by 21-hydroxylation of 17αOHP, measurement of 17αOHP is a useful indirect indicator of 21-hydroxylase activity. In congenital 21-hydroxylase deficiency, the most common variety of congenital adrenal hyperplasia (CAH), 17αOHP is secreted in abundant excess. It is moderately elevated in the 11-b-hydroxylase deficiency as well. Measurement of 17αOHP is therefore valuable in the initial diagnosis of CAH. Key Applications Endocrinology Specifications Analyte / Target - 17OHP (17 alpha hydroxyprogesterone) Diagnostic Platforms - RIA Disease Screened - 17OHP Evaluation - Quantitative Sample Volume - 25 uL Species Reactivity - Human