Leishmaniasis test kit RIDASCREEN®

infectionIgGLeishmania

For in vitro diagnostic use. The RIDASCREEN® Leishmania IgG Test is an enzyme immunoassay for the quantitative determination of specific IgG antibodies against Leishmania infantum in human serum. The test should be used for confirmation purposes when there is a suspected case of Leishmaniasis. General information: Leishmania is in the tropics and subtropics including the Mediterranean region a worldwide distributed parasite. Infection takes place by the bite of sand flies. Three clinical forms of leishmaniasis are known caused by different Leishmania species. Visceral leishmaniasis (kala-azar): The parasites reproduce in the reticuloendothelial (RE) cells of the spleen, liver, lymph nodes, bone marrow, intestinal mucosa and other organs. Untreated disease usually progresses to a fatal termination within 2 years, although fulminating infections may cause death within few weeks. Mucocutaneous leishmaniasis: The clinical appearance and histopathology of mucocutaneous leishmaniasis are identical to cutaneous leishmaniasis, except that it may produce later mucous membrane involvement. The mucosal lesions are painful and can cause great deformity with erosion of the nasal septum, palate, or larynx. Cutaneous leishmaniasis: In humans the disease is limited to the cutaneous tissues and causes an ulcerous papulation. It is the least severe form of the disease. Beside direct parasite detection, antibody detection by ELISA is a suited diagnostic method especially in cases of visceral leishmaniasis. Antibodies can be detected in nearly all patients with visceral leishmaniasis.