Hospital-acquired infection test kit RIDASCREEN®

Clostridium difficilestoolenzyme immunoassay

RIDASCREEN® Clostridium difficile Toxin A/B is an enzyme immunoassay for qualitative determination of the Clostridium difficile toxins A and B in human stool specimens and from cultures of toxin-producing Clostridium difficile strains that were previously cultured from stool specimens. General information: Clostridioides (Clostridium) difficle infection (CDI) is recognized to be one of the most common causes of nosocomial and antibiotic treatment-associated diarrhea. CDI can occur after disturbance of the gut microbiome by the administration of antibiotics, chemotherapeutic agents, immunosuppressants or proton pump inhibitors, as well as by inflammatory bowel diseases or surgical interventions on the digestive tract. Symptoms of the disease include watery diarrhea with a characteristic foul smell, abdominal pain, fever, leukocytosis, and hypoalbuminemia. In severe cases, ileus, pseudomembranous colitis (PMC), toxic megacolon, intestinal perforation, or sepsis can occur. The use of multistage testing algorithms has improved overall diagnostic accuracy being of crucial importance for therapy decisions. After initial screening for C. difficile, testing for toxin A and toxin B is recommended in order to distiguish colonization from infection. RIDASCREEN® Clostridium difficile Toxin A/B supports CDI detection: Direct determination of free C. difficile toxin A and toxin B in the patient specimen Use of monoclonal antibodies for outstanding specificity Obtains reliable results in combination with RIDASCREEN® Clostridium difficile GDH