Compact multi-parameter monitor MAVERICK

temperatureintensive careeasy-to-use

This easy-to-use process analytical technology device offers in-line bioprocess analysis and control with no complex modeling. Measure multiple critical parameters across media, across processes, across mammalian cell lines, across scales. All In-line Gain, No Modeling Pain MAVERICK is powered by Raman spectroscopy and a purpose-built de novo model. The de novo model is explicitly built on media chemistries and device physics, not on empirical data. It automatically interprets the spectra and quantifies process parameters enabling simultaneous measurements of glucose, lactate, and total biomass. This is achieved without the costs, complexities, and risks associated with conventional Process Analytical Technology (PAT) methods. There is no need to grapple with complex empirical models, reagents, or unreliable auto-sampling systems to implement in-line bioprocess analysis. How the De Novo Model Works The MAVERICK measurements are based on a de novo model. This model was developed from first principles without empirical observation/calibration in bioprocesses with any particular media. The de novo model considers both static and dynamic parameters measured during the actual bioprocess runs. One of the static parameters is a formulary which includes the spectral characteristics of many chemical components in media. These include glucose, lactate, and other cell culture media components detectable by Raman. The dynamic parameters include adapting to changes in environmental factors such as ambient light, temperature, and turbidity, including cell based fluorescence.