Fiber optic spectrophotometer PATsmart™ SoloVPE® PLUS

UV-visUVfor the pharmaceutical industry

The new PATsmart™ SoloVPE® PLUS System features patented variable pathlength technology (VPT), providing precise concentration measurements with no need for costly dilutions. This reliable solution delivers fast, accurate results with system-to-system, operator-to-operator, and site-to-site consistency, ensuring high-quality performance across various bioprocessing applications.

Unlike the single value dependence of legacy UV-Vis methods, the data-dense slope method characterizes samples by collecting multiple absorbance data points at several pathlengths to create a section curve (absorbance vs. pathlength plot).

The section curve is then analyzed in real time to verify linearity in compliance with the Beer-Lambert law. The linear region of the section curve is directly proportional to the concentration of the sample based upon the sample extinction coefficient.

The result?

The SoloVPE PLUS System reports concentration results in less than 30 seconds. Capable of making spectral and fixed-point measurements at wavelengths between 190 nm and 1100 nm at pathlengths between 2 microns and 15 millimeters, the SoloVPE PLUS solution is adaptable to a wide range of sample types and concentrations. The variable pathlength spectroscopy method has been proven to be accurate, precise, and robust. Therefore, it can easily and successfully be validated in accordance with ICH Q2(R1) requirements.

The variable pathlength technology allows R2 values of ≥0.999, proving the robust system-to-system consistency.

Key Features

• Dilution-free VPT measurements: The first and only slope spectrometer, based on the science of variable pathlength technology, that allows you to tailor the pathlength and not your concentration, eliminating the need for dilutions.
• Wide dynamic range: The SoloVPE PLUS can measure from wavelengths of 190 nm–1100 nm, and at pathlengths between 2 microns and 15 millimeters, allowing you to measure a range of molecules, ranging from very low to very high concentrations.
• Built-in, rapid accuracy: The SoloVPE PLUS takes up to 10 measurements within 30 seconds, making it the ideal at-line process analytics tool to support Manufacturing, Process Development, and Quality Control operations.
• 21 CFR Part 11 and Annex 11 Software: SoloVPE PLUS comes with proprietary PATsmart™ ViPER® ANLYTX Software, which streamlines and simplifies your workflow and includes has several molecule-based applications to cater to your specific sample. The software contains features such as custom reporting, audit trails, and granular security and admin control, making it ideal for GMP environments and ready for 21 CFR Part 11 and Annex 11 compliance.