Tangential flow filtration system KrosFlo® KR2i RPM®

ultrafiltrationdiafiltrationlaboratory

Monitor concentration in real time during your UF/DF run. Featuring in-line protein concentration management, control your process with the power of the KrosFlo® KR2i TFF System and insights from the integrated PATsmart™ FlowVPX® System, coming together to form the KrosFlo® KR2i Real-Time Process Management (RPM®) System.

Take control of your process with the KrosFlo® KR2i RPM® System

• Strengthen your process control with high accuracy and reproducible results.
• Increase process efficiency by reducing cycling time and increasing yield throughput.
• Reduce process risk by ensuring accurate concentration throughout the TFF process.

Real-time Concentration Insights
In-Line integration of the PATsmart™ FlowVPX® Process to UF/DF operations provides real-time protein concentration monitoring while allowing for feedback control.

Rapid Data Acquisition
The KrosFlo RPM System generates 12 “QC-grade” concentration measurements in 1 minute (5 pathlengths in 5 seconds) with continuous data acquisition during the UF/DF process.

Broad Dynamic Range
Using real-time management allows for concentration measurements from 0.1 mg/ml to 300 mg/ml to be tested without dilution.

Better Accuracy
Variable Pathlength Technology (VPT) allows the system to adjust to the right pathlength range for accurate measurements regardless of the molecule.

Integrated Data Analysis
Integrated Real-Time Process Management Software (KrosFlo® RPM® Software) combines the power of the KR2i automation with the real-time insight from the FlowVPX® System to give you the data you need and the control you’ve always desired.

TFF automation control based on in-line concentration

• Provides real-time overview at every step of the filtration process
• Automatically graphs data and trends of critical inputs and outputs