Automated molecular screening system ICR 8000
medium throughput

automated molecular screening system
automated molecular screening system
automated molecular screening system
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Characteristics

Type
automated
Other characteristics
medium throughput

Description

Aurora Biomed’s Ion Channel Readers (ICR) combine the versatility, precision, and sensitivity of atomic absorption spectroscopy (AAS) with our patented microsampling process and liquid handling technologies, creating a high-throughput screening solution for ion channel researchers that fills gaps, which automated patch-clamp cannot. The ICR 8000 is a more affordable, mid-throughput ion channel screening system which is compact enough for the benchtop, while retaining broad utility. The ICR 8000 can be used to assess both voltage-gated (hERG, BK/SK, Kv1.1, 1.4, 1.5, KCNQ, 2P, etc.) and ligand-gated (KATP, nAChR, etc.) ion channels, as well as ion pumps and transporters (e.g., Na+/K+-ATPase), allowing researchers to accelerate drug development for the treatment and prevention of diseases associated with these key membrane transport proteins. Current applications include the evaluation of the Cation-Chloride Cotransporter (CCC), a critical component of neuronal chloride homeostasis that is an essential regulator of cell volume and neuronal excitability. Because CCCs are electroneutral, their activity cannot be measured using automated patch clamp techniques. The ICR 8000 is able to obtain high throughput activity measurements for these and other channels and transporters by measuring the absolute concentrations of cytosolic and extracellular ions, a technique that is independent of, and complimentary to, methods that rely on voltage manipulation. Specifications Single Channel: Measures 1 sample at a time Minimum sample volume: 50 µl Accommodation: 96/384-well microplates Footprint: H.67 cm X W.55 cm X D.37 cm

Exhibitions

Meet this supplier at the following exhibition(s):

Analytica China 2024
Analytica China 2024

18-20 Nov 2024 Shanghai (China)

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    *Prices are pre-tax. They exclude delivery charges and customs duties and do not include additional charges for installation or activation options. Prices are indicative only and may vary by country, with changes to the cost of raw materials and exchange rates.