HLA-B27 test kit EG-90060-RT
SpAbloodfor real-time PCR

HLA-B27 test kit
HLA-B27 test kit
HLA-B27 test kit
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Characteristics

Applications
SpA
Tested parameter
HLA-B27
Sample type
blood
Analysis mode
for real-time PCR

Description

Intended use EliGene® Spondylitis HLA-B27 RT is intended for the genotypization of HLA-B27 allele (subtypes B*2701-2759) from isolated DNA. Principle of the method This diagnostic kit is based on RealTime PCR method. In this kit primers and labeled probes (FAM and HEX) for the detection of HLA-B27 alleles and for the detection of internal control are used. Introduction Human Leukocyte Antigen (HLA) B27 (subtypes B*2701-2759) is an HLA class I surface antigen that is encoded in the B locus in the major histocompatibility complex (MHC) on the short arm of chromosome 6. In HLA-B27 antigen a strong association with ankylosing spondylitis (AS) and spondyloarthropathies (SpA) was found. Moreover the increased incidence of this antigen in other diseases as Reiter´s syndrome or uveitis was found. Association studies found an association between HLA-B27 antigen and AS in all ethnic and racial groups worldwide however the prevalence of HLA-B27 antigen and the strength of its association with AS does vary. For example, the prevalence of HLA-B27 antigen is about 8% in Caucasians, 4% in North Africans, 2-9% in Chinese, and 0.1-0.5% in Japanese. Further, among northern Europeans only 8% of the general population possesses HLA-B27, but more than 90% of the patients with AS possess this gene. In contrast, among African Americans 2% to 4% of the general population and only 50% to 60% of patients with AS possess this gene.

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