Animal research inhalation chamber S2008R

for preclinical researchveterinary

Overview
The S2008R oronasal aerosol exposure system is designed for controlled inhalation exposure in small laboratory animals (mice, rats) and adaptable to larger species (rabbits, dogs, non-human primates). It supports aerosol dosing, inhalation infection models and inhalation pharmacology studies with particle distributions reaching deep lung regions.

Components

• Aerosol generator (jet nebulizer)
• Exposure tower (universal for mice and rats)
• Airflow controller / bias flow supply
• Exhaust recovery unit with multi-stage active filtration
• Optional: aerosol concentration monitor and aerosol equilibration chamber

Model
S2008R

Applications
Designed for studies such as bronchial asthma, bronchitis, pulmonary fibrosis, COPD, cough/asthma models, inhalation drug screening and safety evaluation, addiction research and euthanasia-related exposure control studies.

Key product features

• Compatible with diverse nebulizable media: dust, liquids, volatile compounds and smoke
• Oronasal exposure minimizes non-respiratory uptake and reduces dermal/ocular contamination
• Active exhaust recovery with multi-stage filtration to protect personnel and environment
• Efficient ventilation and uniform aerosol concentration in chamber; inhalation and exhalation flow paths separated

Aerosol generator description and technical features
Imported jet nebulizer using compressed air through fine nozzles to generate stable fine particles capable of reaching deep lung tissue.

• VMD particle size: 2.0 μm–6 μm; 2.5–5 μm fraction >80% (particle size analysis report available)
• Nebulization rate: 0.6 ml/min (blue core), 0.45 ml/min (red core)
• Aerosol equilibration chamber: ≥φ15 cm × 17 cm to ensure stable, homogeneous aerosol entering the exposure tower
• Bias flow function with adjustable ventilation to maintain stable fresh air and temperature in the chamber

Universal mice/rats exposure tower
Stainless steel tower with interchangeable holders for mice and rats; selectable 1–3 tiers, 8 holders per tier (options: 8 / 16 / 24 channels). Internal diffusion layers separate inhalation and exhalation paths to prevent cross-contamination.

• Mouse holder: φ30 mm × 95 mm
• Rat holder: φ54 mm × 200 mm
• Example tower size: φ500 mm × 800 mm (three-tier, 24 channels)

Exhaust recovery unit and technical features
Active exhaust recovery captures and filters animal exhaled gases at controlled rates to reduce risk to staff and environment.

• Capable of filtering anesthetic agents and toxic gases (e.g., isoflurane, sevoflurane analogs and other hazardous compounds)
• Multi-layer filtration: moisture treatment, scrubber, desiccant, activated carbon adsorption (example configuration)
• Continuous operation >24 hours; standard flow control range 0–5 L/min (optional 0–15 L/min)
• Large-capacity carbon canister >2100 ml; desiccant >500 g; moisture trap >800 ml

Options and customization
Selectable aerosol generator configurations, aerosol concentration monitoring systems and custom gas exposure boxes (e.g., CO2, SO2, CO, O2 control) available on request.

References and application examples (selection)
Includes representative publications and theses related to oronasal inhalation exposure, PM2.5-induced lung injury and neurotoxicity, and inhalation dosing protocols (reference list for example use).

Technical specifications

• Model: S2008R
• Aerosol VMD: 2.0 μm–6 μm (2.5–5 μm fraction >80%)
• Nebulization rate: 0.6 ml/min (blue core), 0.45 ml/min (red core)
• Aerosol equilibration chamber: ≥φ15 cm × 17 cm
• Exposure tower channels: selectable 8 / 16 / 24 channels (1–3 tiers)
• Mouse holder: φ30 mm × 95 mm; Rat holder: φ54 mm × 200 mm
• Exhaust treatment: multi-layer filtration, continuous operation >24 h; standard flow 0–5 L/min (optional 0–15 L/min)
• Carbon canister >2100 ml; desiccant >500 g; moisture trap >800 ml