Manual nebulizer

for researchfor animal researchhand-held

Introduction
The Micro Sprayer Aerosolizer, an endotracheal nebulization drug delivery device, is designed for small animals such as mice, rats and guinea pigs. It enables precise, quantitative intratracheal nebulization by atomizing measured liquid through a micro‑nozzle integrated in a stainless steel capillary, which can be advanced into bronchial bifurcations to deliver aerosolized drug directly into the trachea. Compared with oral or systemic injection, this delivery targets the lungs directly, making it suitable for studies of pulmonary physiology, pathology and pharmacology.

Features

• Advanced liquid atomization technology: Approximately 90% of aerosolized particles are <30 μm, producing a fine, uniform mist that deposits across lung tissues of mice and rats to improve local delivery and experimental consistency.
• Precise dosage control: Direct intratracheal administration avoids first‑pass elimination and minimizes systemic exposure, ensuring the drug uniformly reaches target cells and tissues.
• Compatible sample types: Suitable for solutions, small cell suspensions (up to 15 μm), homogeneous suspensions and low‑viscosity emulsions; minimum accurate dosing from 25 μL enables reproducible microdosing.
• Materials and design: Constructed from imported stainless steel capillary and nozzle for corrosion resistance, mechanical strength and long service life in laboratory environments.
• Simple operation and maintenance: Split design allows guided insertion and piston actuation for rapid lung dosing; optional plugging device facilitates cleaning and maintenance.

Application Areas

• Study pulmonary absorption mechanisms: Administer labeled compounds to measure absorption and transport in alveoli and interstitium and establish pulmonary absorption models.
• Analyze pulmonary metabolism: Detect formation and changes of metabolites in lung tissue after administration and study local metabolic enzyme activity and kinetics.
• Evaluate pulmonary clearance mechanisms: Investigate roles of alveolar macrophages, surfactant and ciliary activity in drug clearance.
• Explore immune response and barrier function: Observe immune cell activation, inflammatory responses and assess endothelial/epithelial permeability with labeled probes.
• Establish pulmonary-systemic pharmacokinetic models: Use intratracheal administration data to model absorption, distribution, metabolism and elimination more accurately.

Atomisation vs. Instillation
Item | Intratracheal Atomisation | Intratracheal Instillation
Anaesthesia | Non-invasive — anaesthesia only | Invasive — after anesthesia, muscle layers must be bluntly separated to expose the trachea
Administration mode | Nebulizer rapidly sprays through the glottis into the trachea | Slow injection after inserting a catheter into the trachea
Post-Dose Procedures | Allow animals to awaken | After injection, the animal should be held upright and rotated to distribute the dose; surgical incision must be sutured
Drug distribution | Drug distributes in punctate or patchy patterns across lobes | Drug distributes in large lumps within lobes
Treatment effect | Consistent with physiological progression of lung disease | Progression may not follow normal physiological conditions
Dye distribution effect | (image omitted) | (image omitted)

Specifications

• Applicable samples: solutions, small cell suspensions (≤15 μm), homogeneous suspensions, low‑viscosity emulsions
• Dose range: 25 μL–250 μL
• Drug aerosol particle size: 10–30 μm
• Atomization reach: up to bronchioles and terminal bronchi
• Single atomization accuracy: 2 μL
• Outer diameter of syringe nozzle: 6.3 mm
• Angle to needle tip length: 46 mm (rat), 27 mm (mouse) — custom lengths supported
• Needle tail to angle length: 15 mm
• Needle bend angle: 120°