MS spectrometer Q Exactive™ Plus

FT-MSMS/MSfor life sciences applications

Product overview
The Thermo Scientific™ Q Exactive™ Plus Hybrid Quadrupole‑Orbitrap Mass Spectrometer combines high‑resolution accurate‑mass Orbitrap analysis with an advanced quadrupole for targeted precursor selection, enabling routine qualitative and quantitative LC‑MS workflows on a single platform.

Superior Quantitation

• Advanced quadrupole technology (AQT) improves precursor selection and transmission for more accurate quantitation of low‑abundance analytes in complex matrices
• Data‑independent acquisition (DIA) and parallel reaction monitoring (PRM) provide reproducible quantitation with full qualitative confidence
• Advanced active beam guide (AABG) reduces background noise and extends maintenance intervals

Enhanced Analysis of Intact Proteins

• Optional intact protein mode improves trapping of large molecules for analysis of intact proteins and protein complexes
• Optional enhanced resolution modes support top‑down proteomics and lipidomics identification workflows

High‑Confidence Results

• HR/AM full‑scan capabilities capture complete sample data for retrospective analysis without re‑running samples
• Resolving power up to 140,000 FWHM (up to 240,000 at m/z 200) to reduce isobaric interferences
• Mass accuracy better than 1 ppm (internal) in full‑scan and AIF modes for confident compound identification
• Fast scanning up to 12 Hz and spectral multiplexing for UHPLC applications
• Rapid polarity switching maximizes information per injection
• AIF and multiple dissociation techniques (in‑source CID, HCD) support structural elucidation
• Mass range up to 6000 m/z for detection of singly charged small molecules and higher‑mass biomolecules
• Intrascan dynamic range >5000:1 and femtogram‑level sensitivity enable detection of trace and high‑abundance compounds in a single scan

Notes
For Research Use Only. Not for use in diagnostic procedures.

Product identifiers / selection table
Catalog Number: IQLAAEGAAPFALGMBDK
Scan Rates: Up to 12 Hz
Mass Range: 50 to 6000 m/z

Technical specifications

• Dynamic Range: >5000:1
• Mass Accuracy: Internal: <1 ppm RMS; External: <3 ppm RMS
• Polarity Switching: One full cycle in <1 sec (one positive and one negative full scan at 35,000 res.)
• Scan Rates: Up to 12 Hz
• Sensitivity: Full MS: 500 fg Buspirone on Column S/N 100:1; SIM: 30 fg Buspirone on Column S/N 100:1
• Mass Range: 50 to 6000 m/z
• Max. Resolution: Up to 240,000 at m/z 200
• Type: Quadrupole‑Orbitrap LC‑MS
• Unit Size: Each