Radiochemistry synthesis platform NEPTIS® Perform

radiotracerPETrobotized

Product overview
NEPTIS® Perform is the standard platform for advanced tracers. Perform produces the widest range of [18F] fluoride-based radiotracers via nucleophilic synthesis, including tracers that require HPLC. Complex chemistry becomes routine, enabling on-schedule production and reliable daily doses.

Supported tracers (examples)

• [18F]FDG
• [18F]NaF
• [18F]FLT
• [18F]FMISO
• [18F]FCH
• [18F]FET
• [18F]FES
• [18F]F-L-DOPA
• [18F]FHBG
• [18F]PSMA1007
• [68Ga]Ga-tracers
• [177Lu]Lu-tracers

Key benefits

• Make complex [18F] chemistry routine: handles a wide [18F] portfolio including advanced tracers used in research (e.g. Alzheimer's) and clinical use.
• One validated sequence, doses on time: cassette-based setup, browser-based NEPTIS® software and on-board HPLC/SPE orchestrate injection, separation and clean-up as a single guided sequence.
• Future-proof and scalable: dedicated integrated HPLC drawer, UV detection and on-board SPE reformulation; additions (extra detectors, second oven, quaternary pump, FDG dual-run options) available to grow with pipeline.
• Reliable operation: patented WNE® 3-position pneumatic actuators control in-cell motion; CPU outside the hot cell and UV via optical fibers reduce electronics exposure to radiation for fewer failure points and higher uptime.

How it works
Modular cassette-based synthesizer combined with browser-based NEPTIS® Control. The platform integrates injection, separation and clean-up sequences (including on-board HPLC and SPE) into a single guided method run, with Designer and Trending for method development and run analytics.

Applications & positioning
Designed for radiochemistry laboratories and radiopharmacies producing a broad range of fluoride-based tracers (nucleophilic syntheses) and radiometals, enabling routine production of complex tracers and facilitating expansion of tracer portfolios without reconfiguration.

Technical specifications

• Actuators: 4 ramps × 5 pneumatic (3-position) actuators (WNE® system)
• HPLC (option): Integrated drawer; software-controlled pump/valve; optional quaternary pump
• Detectors: 5 radioactivity detectors (+1 optional)
• Hot cell compatibility: Fits standard shielded hot cells
• Syringe drivers: 3 (30 mL and 10/3 mL)
• Dimensions (w × h × d): 560 × 420 × 400 mm (22.0 × 16.5 × 15.7 in)
• Heating & Reactor ovens: 1 (+1 optional)
• Weight: 38 kg / 84 lbs
• Sensors: Vacuum, flow and pressure
• Ready-to-use cassettes: Yes (ready-to-use cassettes available)
• UV detection: MWD UV detector via optical fibers (electronics protected)
• Software: Browser-based NEPTIS® Control with Designer and Trending for method development and run analytics