Radiotracer synthesis platform NEPTIS® DB

for glycose moleculesPETradiochemistry

Short description
The Reference for Routine Production.

Supported tracers

• [18F]FDG
• [18F]NaF
• [18F]FLT
• [18F]FMISO
• [18F]FCH
• [18F]F‑L‑DOPA
• [68Ga]Ga‑tracers
• [177Lu]Lu‑tracers
• FET, PSMA‑1007 and other 18F fluoride‑based radiotracers

Key benefits & capabilities

• HPLC‑free routine production: Designed for day‑in, day‑out [18F] synthesis without HPLC for tracers that do not require column purification.
• Stack to scale: Two DB modules fit in a single mini‑cell; capacity can be increased without additional hot‑cell footprint and consecutive runs can be automated with cleaning between runs.
• Proven throughput: Supports dual FDG runs with reported yields >70% and enables increased production capacity by stacking modules.
• Multi‑purpose platform: Produces a broad panel of 18F fluoride‑based radiotracers via nucleophilic synthesis on the same module to cover routine clinical demand.
• Non‑proprietary consumables: Compatible with commercially available consumables and with TracerLab Mx cassette and chemicals for drop‑in use at sites with an existing installed base.
• Reliability by design: Patented WNE® 3‑position pneumatic actuators control in‑cell motion without electronics in the radiation field; CPU is located outside the hot cell to reduce failure modes and increase uptime.

Design & automation

• Browser‑based NEPTIS® Control software with Designer and Trending for method development and run analytics.
• Automated cleaning between runs to minimize operator intervention and cross‑contamination risk.
• Pinch valves using pneumatic technology for compact, robust in‑cell fluid control.

Operational features

• Ready‑to‑use cassettes available to simplify setup and reduce changeover time.
• Use of commercially available consumables to keep cost per run predictable.
• Patented WNE® pneumatic actuator system for in‑cell motion control without electronics in the radiation field.

Use cases
The NEPTIS® DB is intended for routine clinical and production environments requiring reliable HPLC‑free synthesis of a wide range of fluoride‑based tracers, with options to scale capacity by stacking modules within mini‑cells.

Technical specifications

• Actuators: 3 ramps × 5 pneumatic (3‑position) actuators (WNE® system)
• Hot cell compatibility: Up to two modules in one mini‑cell
• Detectors: 3 radioactivity detectors (+1 optional)
• Dimensions (w × d × h): 560 × 240 × 400 mm (22.0 × 9.4 × 15.7 in)
• Weight: 28 kg / 61 lbs
• Syringe drivers: 3 (30 mL and 10/3 mL)
• Heating & Reactor ovens: 1 (+1 optional)
• Ready‑to‑use cassettes available: Yes
• Valves: Pinch valves, pneumatic technology
• Software: Browser‑based NEPTIS® Control with Designer and Trending
• Sensors: Vacuum, flow and pressure
• Typical supported tracers: FDG, NaF, FCH, FET, PSMA‑1007, FLT, FMISO, F‑L‑DOPA, Ga‑ and Lu‑based tracers