Radiotracer synthesis platform Synthera®+

PETradiochemistryfor glycose molecules

Product overview
Synthera®+ Platform is an automated, cassette-based radiopharmaceutical synthesis system designed for compact hot-cell integration and flexible multi-tracer production workflows. The platform supports modular add-ons to scale from research to routine clinical manufacturing.

Supported tracers (examples)

• [18F]FDG
• [18F]PSMA1007
• [18F]NaF
• [18F]FET
• [18F]FLT
• [18F]FMISO
• [18F]FCH
• [18F]FES
• Neuraceq®

Key benefits & features

• Multi-tracer capacity — enables production of different tracers across consecutive runs.
• Back-to-back multi-run operation — independent radiosynthesis of different tracers without opening the hot cell when used with the IFP™ Loader; the IFP™ Loader can multiply module capacity by four.
• Space-efficient design — compact footprint for optimized hot cell utilization and facility integration.
• Accessory-based modularity — base system with optional modules (HPLC, automated loader, extension modules) to expand functionality.
• Radiation-tolerant hardware — engineered for extended operational lifetime and reduced maintenance.
• Disposable consumables — integrated single-use cassettes to minimize cross-contamination and simplify changeover.

System components & operational highlights

• IFP™ automated cassette loader (optional) — increases throughput and enables multi-run workflows.
• Synthera®+ HPLC integration options for purification and QC.
• Disposable cassette-based fluidics to reduce cross-contamination risk and simplify maintenance.

Process & control elements

• Heating & reactor ovens: heating up to 180°C.
• Valves: 8 (system configuration documented on product page).
• Vacuum pump: 1.
• Sensors: integrated radiation, temperature, gas and compressed air monitoring.

Dimensions (product configurations)
Synthera®+ Synthesizer: 178 x 271 x 247 mm / 7 x 10.7 x 9.7 in (w x d x h)
IFP™ automated loader: 230 x 292 x 387 mm / 9 x 11.5 x 15.2 in (w x d x h)
Synthera®+ HPLC: 93 x 240 x 247 mm / 3.7 x 9.5 x 9.7 in (w x d x h)
Synthera®+ Extension: 132 x 170 x 170 mm / 5.2 x 6.7 x 6.7 in (w x d x h)

Applications

• Routine clinical production of fluorine-18 labeled radiopharmaceuticals (e.g., [18F]FDG).
• Support for clinical trials and translational R&D of investigational PET tracers.
• Flexible deployment from research laboratories to routine production environments.

Accessories & consumables

• Disposable single-use cassettes (fully integrated)
• Automated cassette loader (IFP™)
• HPLC module and optional extension modules to expand capabilities

caractéristiques / spécifications techniques

• Heating: up to 180°C.
• Valves: 8.
• Vacuum pump: 1.
• Sensors: radiation, temperature, gas and compressed air monitoring.
• Synthera®+ Synthesizer dimensions: 178 x 271 x 247 mm (w x d x h).
• IFP™ automated loader dimensions: 230 x 292 x 387 mm (w x d x h).
• Synthera®+ HPLC dimensions: 93 x 240 x 247 mm (w x d x h).
• Synthera®+ Extension dimensions: 132 x 170 x 170 mm (w x d x h).
• Multi-run capability with optional IFP™ Loader to support consecutive productions without hot cell access.
• Accessory-based modular architecture to scale functionality over time.