Radiochemistry synthesis platform NEPTIS® xSeed™

robotized

Overview
NEPTIS® xSeed™ is a next‑generation radiochemistry research module engineered for rapid method development and direct transfer to NEPTIS® production modules. It supports multi‑run automated workflows with in‑cell automated cleaning and cartridge reconditioning, enabling up to four consecutive runs of different sequences. Sequences validated on xSeed transpose directly to NEPTIS® production modules (FX/FN compatibility), minimizing rework when scaling from R&D to cassette‑based production.

Key features

• Faster method development: designed for high‑frequency method testing with up to four consecutive runs of different sequences and automated in‑cell cleaning and cartridge reconditioning between runs.
• Direct path to production: validated sequences are directly transferable to NEPTIS® production modules (no rework required); FX/FN sequence compatibility facilitates scale‑up from R&D to production.
• Low waste / cost efficiency: supports non‑disposable kit designs and associated packs to avoid repeated purchase/modification/disposal of costly cassettes during development.
• Reliable platform: patented WNE® 3‑position pneumatic actuators control in‑cell motion; UV detection via optical fibers (VWD); CPU located outside the hot cell for stability under intensive multi‑run use.

Product description
NEPTIS® xSeed™ targets radiochemistry R&D teams that require rapid cycle method development and straightforward scale‑up to production. The module provides multi‑run automated workflows, extensive reagent handling flexibility, and in‑process monitoring with multiple detectors. Its architecture is built for stability during intensive development campaigns and to protect prior method‑development investment by enabling direct transfer of validated methods to production NEPTIS® modules.

Technical specifications

• Actuators: 4 ramps × 5 pneumatic (3‑position) actuators (WNE® system)
• Cleaning: Automated cleaning system for multi‑run operation
• Heating & reactor ovens: 2 heating zones with cooling; option for 1 classical oven + 1 Peltier
• Reaction volume: 1.5 to 6.0 mL
• Reagent handling: 20 positions for vials/cartridges; vial sizes 1–50 mL
• Dimensions (w × d × h): 560 × 420 × 410 mm (22.0 × 16.5 × 16.1 in)
• Detectors: 6 shielded radioactivity detectors for process monitoring; UV (VWD) detection via optical fibers
• Weight: 38 kg / 84 lbs
• Syringe drivers: 3 (30 mL and 10/3 mL)
• Ready‑to‑use cassettes available: No (supports non‑disposable kit design)
• [18O] water recovery: Supported (QMA recycling)
• Software: Browser‑based NEPTIS® Control with Designer and Trending for method development and run analytics