Granulator for the pharmaceutical industry ROTO MIX series

for productionwetdry

Overview
ROTO MIX is a next-generation high-shear mixer granulator designed for dry powder mixing and wet granulation in pharmaceutical production. The system promotes efficient particle agglomeration via the coordinated action of an impeller, chopper and liquid binder distributor and is available with a through-the-wall configuration to simplify facility layout and integration.

Highlights

• Suitable for high containment: minimises product transfers and contact surfaces to reduce handling and contamination risk.
• Clean and controlled process: dust-free operation, safe solvent handling and improved contamination control.
• Impeller innovation: impeller geometry reduces product sticking and improves yield.
• Easily integrated: through-the-wall installation and compatibility with downstream granulation equipment.
• Dry milling option: in-line dry milling for wet granule sizing and direct transfer to fluid bed dryers.
• Effective cleaning: Wash-In-Place (WIP) via strategically positioned nozzles for thorough cleaning.

Functional components / Equipment features

• Impeller: engineered to maximise mixing and agglomeration efficiency while minimising product adherence.
• Chopper: high-speed chopper for granulate control (700–1,450 rpm standard; up to 2,000 rpm with frequency converter on some models).
• Liquid binder distributor: designed for uniform binder spray to ensure consistent granule formation.
• Washing nozzles: positioned to provide effective Wash-In-Place coverage.
• Through-the-wall configuration: optimises room layout and simplifies integration with adjacent equipment.
• In-line dry milling option: enables wet granule sizing and direct transfer to downstream dryers.

Technical data (table)
Bowl capacity (l) | 30 | 60 | 120 | 300 | 600 | 900 | 1,200 | 1,500 | 2,500
Working capacity (l) | Minimum 25% – Maximum 70%
Impeller power (kW) | 3 | 4 | 11 | 18.5 | 30 | 45 | 55 | 75 | 115
Impeller speed (rpm) | 20-345 | 15-275 | 15-220 | 10-165 | 10-130 | 10-115 | 10-100 | 10-97 | 6-82
Chopper speed (rpm) | 700-1,450 (up to 2,000 with frequency converter)

Machine dimensions (table)
Model | 30 | 60 | 120 | 300 | 600 | 900 | 1200 | 1500 | 2500
Recommended batch size (litres) | 7-22 | 15-45 | 30-90 | 75-225 | 150-450 | 225-675 | 300-900 | 375-1125 | 625-1875
A (mm) | 1,250 | 1,400 | 1,650 | 2,100 | 2,300 | 2,550 | 2,700 | 2,850 | 3,500
B (mm) | 1,260 | 1,250 | 1,550 | 1,900 | 2,300 | 2,550 | 2,700 | 2,830 | 3,020
C (mm) | 800 | 680 | 770 | 950 | 1,240 | 1,270 | 1,300 | 1,350 | 1,350
D (mm) | 600 | 850 | 1,050 | 1,300 | 1,500 | 1,700 | 1,800 | 1,900 | 2,350
E (mm) | 800 | 1,700 | 1,980 | 2,300 | 2,900 | 3,250 | 3,250 | 3,400 | 3,700
Impeller speed range (rpm) | 20-345 | 15-275 | 15-220 | 10-165 | 10-130 | 10-115 | 10-100 | 10-97 | 10-82
Chopper speed range (rpm) | 700-1,500 (general range)

Notes
Key functions: dry mixing, wet granulation, optional in-line dry milling, Wash-In-Place capability and through-the-wall installation. Designed for pharmaceutical granule manufacturing with emphasis on containment, cleanability and product yield.

Technical specifications

• Bowl capacities: 30–2,500 L across multiple models.
• Working fill range: 25%–70% of bowl capacity.
• Impeller power: from 3 kW up to 115 kW depending on model.
• Impeller and chopper speed ranges: model dependent (see table).
• Chopper standard speed: 700–1,450 rpm; up to 2,000 rpm with frequency converter on selected models.
• Wash-In-Place system with strategically placed nozzles for thorough cleaning.
• Through-the-wall installation option to optimise plant layout and integration.
• Typical applications: pharmaceutical granulation, high-containment processes, dry milling and granule sizing.